Endothelin 1 in cancer: Biological implications and therapeutic opportunities

Laura Rosanò, Francesca Spinella, Anna Bagnato

Research output: Contribution to journalArticle

Abstract

Activation of autocrine and paracrine signalling by endothelin 1 (ET1) binding to its receptors elicits pleiotropic effects on tumour cells and on the host microenvironment. This activation modulates cell proliferation, apoptosis, migration, epithelial-to-mesenchymal transition, chemoresistance and neovascularization, thus providing a strong rationale for targeting ET1 receptors in cancer. In this Review, we discuss the advances in our understanding of the diverse biological roles of ET1 in cancer and describe the latest preclinical and clinical progress that has been made using small-molecule antagonists of ET1 receptors that inhibit ET1-driven signalling.

Original languageEnglish
Pages (from-to)637-651
Number of pages15
JournalNature Reviews Cancer
Volume13
Issue number9
DOIs
Publication statusPublished - Sep 2013

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Endothelin 1 in cancer: Biological implications and therapeutic opportunities'. Together they form a unique fingerprint.

  • Cite this