Abstract
Aims: To evaluate whether endothelin-1 is involved in the pathology of idiopathic pulmonary fibrosis (IPF). Methods: Plasma endothelin-1 concentrations were evaluated in 37 patients with IPF and 27 normal controls by radioimmunoassay. In addition, expression of endothelin-1 in lung tissue was evaluated in biopsy specimens obtained from four patients with IPF. Three biopsy specimens of normal lung were used as controls. Endothelin-1 immunoreactivity was detected using immunohistochemistry. Results: Elevated endothelin-1 plasma concentrations were found in patients with IPF compared with controls and a positive correlation was found with duration of disease. No significant difference was observed between treated and untreated patients with IPF. Increased endothelin-1 immunoreactivity was found in lungs of three of four patients with IPF. Endothelin-1 positive cells consisted mainly of small vessel endothelial cells. Some scattered macrophages were also positive. Conclusions: Elevated plasma concentrations and expression of endothelin-1 in lung tissue are suggestive of increased production of endothelin-1 in at least a proportion of patients with IPF. Consequently, endothelin-1 activity could play a role in the fibrogenic process of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 330-334 |
| Number of pages | 5 |
| Journal | Journal of Clinical Pathology |
| Volume | 48 |
| Issue number | 4 |
| Publication status | Published - 1995 |
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Keywords
- Endothelin
- Idiopathic pulmonary fibrosis
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Endothelin-1 in idiopathic pulmonary fibrosis. / Uguccioni, M.; Pulsatelli, L.; Grigolo, B.; Facchini, A.; Cinti, C.; Fabbri, M.; Gasbarrini, G.; Meliconi, R.
In: Journal of Clinical Pathology, Vol. 48, No. 4, 1995, p. 330-334.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endothelin-1 in idiopathic pulmonary fibrosis
AU - Uguccioni, M.
AU - Pulsatelli, L.
AU - Grigolo, B.
AU - Facchini, A.
AU - Cinti, C.
AU - Fabbri, M.
AU - Gasbarrini, G.
AU - Meliconi, R.
PY - 1995
Y1 - 1995
N2 - Aims: To evaluate whether endothelin-1 is involved in the pathology of idiopathic pulmonary fibrosis (IPF). Methods: Plasma endothelin-1 concentrations were evaluated in 37 patients with IPF and 27 normal controls by radioimmunoassay. In addition, expression of endothelin-1 in lung tissue was evaluated in biopsy specimens obtained from four patients with IPF. Three biopsy specimens of normal lung were used as controls. Endothelin-1 immunoreactivity was detected using immunohistochemistry. Results: Elevated endothelin-1 plasma concentrations were found in patients with IPF compared with controls and a positive correlation was found with duration of disease. No significant difference was observed between treated and untreated patients with IPF. Increased endothelin-1 immunoreactivity was found in lungs of three of four patients with IPF. Endothelin-1 positive cells consisted mainly of small vessel endothelial cells. Some scattered macrophages were also positive. Conclusions: Elevated plasma concentrations and expression of endothelin-1 in lung tissue are suggestive of increased production of endothelin-1 in at least a proportion of patients with IPF. Consequently, endothelin-1 activity could play a role in the fibrogenic process of the disease.
AB - Aims: To evaluate whether endothelin-1 is involved in the pathology of idiopathic pulmonary fibrosis (IPF). Methods: Plasma endothelin-1 concentrations were evaluated in 37 patients with IPF and 27 normal controls by radioimmunoassay. In addition, expression of endothelin-1 in lung tissue was evaluated in biopsy specimens obtained from four patients with IPF. Three biopsy specimens of normal lung were used as controls. Endothelin-1 immunoreactivity was detected using immunohistochemistry. Results: Elevated endothelin-1 plasma concentrations were found in patients with IPF compared with controls and a positive correlation was found with duration of disease. No significant difference was observed between treated and untreated patients with IPF. Increased endothelin-1 immunoreactivity was found in lungs of three of four patients with IPF. Endothelin-1 positive cells consisted mainly of small vessel endothelial cells. Some scattered macrophages were also positive. Conclusions: Elevated plasma concentrations and expression of endothelin-1 in lung tissue are suggestive of increased production of endothelin-1 in at least a proportion of patients with IPF. Consequently, endothelin-1 activity could play a role in the fibrogenic process of the disease.
KW - Endothelin
KW - Idiopathic pulmonary fibrosis
UR - http://www.scopus.com/inward/record.url?scp=0028946351&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028946351&partnerID=8YFLogxK
M3 - Article
C2 - 7615852
AN - SCOPUS:0028946351
VL - 48
SP - 330
EP - 334
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 4
ER -