Endothelin-1-induced cerebral ischemia: Effects of ketanserin and MK-801 on limb placing in rats

S. Moyanova; L. Kortenska; R. Mitreva

doi:10.1080/00207450600938847

Endothelin-1-induced cerebral ischemia: Effects of ketanserin and MK-801 on limb placing in rats

S. Moyanova, L. Kortenska, R. Mitreva

www.neuromed.it

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Abstract

The long-term effects of the 5-HT_2A receptor antagonist ketanserin on deficits in sensorimotor integration (limb placing tests) following transient focal cerebral ischemia in rats were compared to the effects of the NMDA antagonist MK-801. Middle cerebral artery occlusion was induced in conscious rats by microinjection of endothelin-1 in the vicinity of the artery (EMCAO model). The EMCAO/vehicle rats exhibited impaired tactile and proprioceptive limb placing. In contrast to ketanserin, MK-801 exerted severe early behavioral disturbances, but both drugs significantly improved the neurological scores much earlier than the spontaneous recovery of function occurred. The present results suggest that pharmacotherapy by means of ketanserin lacking the severe side effects of the NMDA antagonists can be used to enhance functional recovery after stroke.

Original language	English
Pages (from-to)	1361-1381
Number of pages	21
Journal	International Journal of Neuroscience
Volume	117
Issue number	9
DOIs	https://doi.org/10.1080/00207450600938847
Publication status	Published - Sep 2007

Keywords

5-HT receptor
Endothelin-1 model of brain ischemia
Middle cerebral artery occlusion
Neurological deficit
NMDA receptor

ASJC Scopus subject areas

Neuroscience(all)

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10.1080/00207450600938847

Cite this

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title = "Endothelin-1-induced cerebral ischemia: Effects of ketanserin and MK-801 on limb placing in rats",

abstract = "The long-term effects of the 5-HT2A receptor antagonist ketanserin on deficits in sensorimotor integration (limb placing tests) following transient focal cerebral ischemia in rats were compared to the effects of the NMDA antagonist MK-801. Middle cerebral artery occlusion was induced in conscious rats by microinjection of endothelin-1 in the vicinity of the artery (EMCAO model). The EMCAO/vehicle rats exhibited impaired tactile and proprioceptive limb placing. In contrast to ketanserin, MK-801 exerted severe early behavioral disturbances, but both drugs significantly improved the neurological scores much earlier than the spontaneous recovery of function occurred. The present results suggest that pharmacotherapy by means of ketanserin lacking the severe side effects of the NMDA antagonists can be used to enhance functional recovery after stroke.",

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author = "S. Moyanova and L. Kortenska and R. Mitreva",

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T2 - Effects of ketanserin and MK-801 on limb placing in rats

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AU - Kortenska, L.

AU - Mitreva, R.

PY - 2007/9

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N2 - The long-term effects of the 5-HT2A receptor antagonist ketanserin on deficits in sensorimotor integration (limb placing tests) following transient focal cerebral ischemia in rats were compared to the effects of the NMDA antagonist MK-801. Middle cerebral artery occlusion was induced in conscious rats by microinjection of endothelin-1 in the vicinity of the artery (EMCAO model). The EMCAO/vehicle rats exhibited impaired tactile and proprioceptive limb placing. In contrast to ketanserin, MK-801 exerted severe early behavioral disturbances, but both drugs significantly improved the neurological scores much earlier than the spontaneous recovery of function occurred. The present results suggest that pharmacotherapy by means of ketanserin lacking the severe side effects of the NMDA antagonists can be used to enhance functional recovery after stroke.

AB - The long-term effects of the 5-HT2A receptor antagonist ketanserin on deficits in sensorimotor integration (limb placing tests) following transient focal cerebral ischemia in rats were compared to the effects of the NMDA antagonist MK-801. Middle cerebral artery occlusion was induced in conscious rats by microinjection of endothelin-1 in the vicinity of the artery (EMCAO model). The EMCAO/vehicle rats exhibited impaired tactile and proprioceptive limb placing. In contrast to ketanserin, MK-801 exerted severe early behavioral disturbances, but both drugs significantly improved the neurological scores much earlier than the spontaneous recovery of function occurred. The present results suggest that pharmacotherapy by means of ketanserin lacking the severe side effects of the NMDA antagonists can be used to enhance functional recovery after stroke.

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Endothelin-1-induced cerebral ischemia: Effects of ketanserin and MK-801 on limb placing in rats

Abstract

Keywords

ASJC Scopus subject areas

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