Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats

A. Fraticelli; L. Rossi; A. I. Socillo; C. Boria; M. C. Capogrossi; E. Paciaroni

doi:10.1016/S0167-4943(05)80015-9

Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats

A. Fraticelli, L. Rossi, A. I. Socillo, C. Boria, M. C. Capogrossi, E. Paciaroni

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

The contractile response to Endothelin-1 (ET-1) has been investigated in electrically stimulated single cardiac myocytes isolated from hearts of young and senescent rats. ET-1 (0.1-10 nM) exhibited a marked negative inotropic effect in both age groups. ET-1 (1.0 nM) also reduced the occurrence of spontaneous contractile oscillations in young myocytes, suggesting depletion of sarcoplasmic reticulum-Ca²⁺ stores. The possibility that ET-1 may have opposite effects on myocardial contractility is discussed.

Original language	English
Pages (from-to)	151-158
Number of pages	8
Journal	Archives of Gerontology and Geriatrics
Volume	15
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/S0167-4943(05)80015-9
Publication status	Published - 1992

Keywords

aging
cardiac myocytes
Endothelin-1
negative inotropism

ASJC Scopus subject areas

Ageing
Geriatrics and Gerontology
Gerontology
Health(social science)
Medicine(all)

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10.1016/S0167-4943(05)80015-9

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title = "Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats",

abstract = "The contractile response to Endothelin-1 (ET-1) has been investigated in electrically stimulated single cardiac myocytes isolated from hearts of young and senescent rats. ET-1 (0.1-10 nM) exhibited a marked negative inotropic effect in both age groups. ET-1 (1.0 nM) also reduced the occurrence of spontaneous contractile oscillations in young myocytes, suggesting depletion of sarcoplasmic reticulum-Ca2+ stores. The possibility that ET-1 may have opposite effects on myocardial contractility is discussed.",

keywords = "aging, cardiac myocytes, Endothelin-1, negative inotropism",

author = "A. Fraticelli and L. Rossi and Socillo, {A. I.} and C. Boria and Capogrossi, {M. C.} and E. Paciaroni",

year = "1992",

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T1 - Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats

AU - Fraticelli, A.

AU - Rossi, L.

AU - Socillo, A. I.

AU - Boria, C.

AU - Capogrossi, M. C.

AU - Paciaroni, E.

PY - 1992

Y1 - 1992

N2 - The contractile response to Endothelin-1 (ET-1) has been investigated in electrically stimulated single cardiac myocytes isolated from hearts of young and senescent rats. ET-1 (0.1-10 nM) exhibited a marked negative inotropic effect in both age groups. ET-1 (1.0 nM) also reduced the occurrence of spontaneous contractile oscillations in young myocytes, suggesting depletion of sarcoplasmic reticulum-Ca2+ stores. The possibility that ET-1 may have opposite effects on myocardial contractility is discussed.

AB - The contractile response to Endothelin-1 (ET-1) has been investigated in electrically stimulated single cardiac myocytes isolated from hearts of young and senescent rats. ET-1 (0.1-10 nM) exhibited a marked negative inotropic effect in both age groups. ET-1 (1.0 nM) also reduced the occurrence of spontaneous contractile oscillations in young myocytes, suggesting depletion of sarcoplasmic reticulum-Ca2+ stores. The possibility that ET-1 may have opposite effects on myocardial contractility is discussed.

KW - aging

KW - cardiac myocytes

KW - Endothelin-1

KW - negative inotropism

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JO - Archives of Gerontology and Geriatrics

JF - Archives of Gerontology and Geriatrics

SN - 0167-4943

IS - SUPPL. 1

ER -

Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats

Abstract

Keywords

ASJC Scopus subject areas

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