Abstract
The contractile response to Endothelin-1 (ET-1) has been investigated in electrically stimulated single cardiac myocytes isolated from hearts of young and senescent rats. ET-1 (0.1-10 nM) exhibited a marked negative inotropic effect in both age groups. ET-1 (1.0 nM) also reduced the occurrence of spontaneous contractile oscillations in young myocytes, suggesting depletion of sarcoplasmic reticulum-Ca2+ stores. The possibility that ET-1 may have opposite effects on myocardial contractility is discussed.
Original language | English |
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Pages (from-to) | 151-158 |
Number of pages | 8 |
Journal | Archives of Gerontology and Geriatrics |
Volume | 15 |
Issue number | SUPPL. 1 |
DOIs | |
Publication status | Published - 1992 |
Keywords
- aging
- cardiac myocytes
- Endothelin-1
- negative inotropism
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
- Gerontology
- Health(social science)
- Medicine(all)