Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats

A. Fraticelli, L. Rossi, A. I. Socillo, C. Boria, M. C. Capogrossi, E. Paciaroni

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Abstract

The contractile response to Endothelin-1 (ET-1) has been investigated in electrically stimulated single cardiac myocytes isolated from hearts of young and senescent rats. ET-1 (0.1-10 nM) exhibited a marked negative inotropic effect in both age groups. ET-1 (1.0 nM) also reduced the occurrence of spontaneous contractile oscillations in young myocytes, suggesting depletion of sarcoplasmic reticulum-Ca2+ stores. The possibility that ET-1 may have opposite effects on myocardial contractility is discussed.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalArchives of Gerontology and Geriatrics
Volume15
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1992

Keywords

  • aging
  • cardiac myocytes
  • Endothelin-1
  • negative inotropism

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)
  • Medicine(all)

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    Fraticelli, A., Rossi, L., Socillo, A. I., Boria, C., Capogrossi, M. C., & Paciaroni, E. (1992). Endothelin-1 may act as a negative inotropic agent in cardiac myocytes from young and senescent rats. Archives of Gerontology and Geriatrics, 15(SUPPL. 1), 151-158. https://doi.org/10.1016/S0167-4943(05)80015-9