Endothelium and haemorheology

Tommaso Gori, Saverio Dragoni, Giuseppe Di Stolfo, Sandro Forconi

Research output: Contribution to journalArticle

Abstract

Summary. The vascular endothelium has been recognized to have a central importance in maintaining vascular homeostasis and in preventing cardiovascular disease. The mechanisms underlying the regulation of its function are extremely complex, and are principally determined by physical forces imposed on the endothelium by the flowing blood. In the present paper, we describe the interactions between the rheological properties of blood and the vascular endothelium. The role of shear stress, viscosity, cell-cell interactions, as well as the molecular mechanisms that are important for the transduction of these signals are discussed both in physiology and in pathology, with a particular attention to the role of reactive oxygen species. In the final conclusions, we propose an hypothesis regarding the implications of changes in blood viscosity, and particularly on the significance of secondary hyperviscosity syndromes.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalAnnali dell'Istituto Superiore di Sanita
Volume43
Issue number2
Publication statusPublished - 2007

Keywords

  • Endothelium
  • Haemorheology
  • Viscosity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Gori, T., Dragoni, S., Di Stolfo, G., & Forconi, S. (2007). Endothelium and haemorheology. Annali dell'Istituto Superiore di Sanita, 43(2), 124-129.