Endovascular Stroke Treatment of Acute Tandem Occlusion: A Single-Center Experience

Fabrizio Sallustio, Caterina Motta, Giacomo Koch, Silvia Pizzuto, Bruce C.V. Campbell, Marina Diomedi, Barbara Rizzato, Alessandro Davoli, Giorgio Loreni, Daniel Konda, Matteo Stefanini, Sebastiano Fabiano, Enrico Pampana, Paolo Stanzione, Roberto Gandini

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Abstract

Purpose To evaluate outcomes and prognostic factors in patients with acute ischemic stroke caused by tandem internal carotid artery/middle cerebral artery occlusion undergoing endovascular treatment. Materials and Methods Characteristics of consecutive patients with tandem occlusion (TO) were extracted from a prospective registry. Collateral vessel quality on pretreatment computed tomographic (CT) angiography was evaluated on a 4-point grading scale, and patients were dichotomized as having poor or good collateral flow. Outcome measures included successful reperfusion according to Thrombolysis In Cerebral Infarction score, good outcome at 3 months defined as a modified Rankin scale score ≤ 2, symptomatic intracranial hemorrhage (ICH; sICH), and mortality. Results A total of 72 patients with TO (mean age, 65.6 y ± 12.8) were treated. Intravenous thrombolysis was performed in 54.1% of patients, and a carotid stent was inserted in 48.6%. Successful reperfusion was achieved in 64% of patients, and a good outcome was achieved in 32%. sICH occurred in 12.5% of patients, and the overall mortality rate was 32%. Univariate analysis demonstrated that good outcome was associated with good collateral flow (P = .0001), successful reperfusion (P = .001), and lower rate of any ICH (P = .02) and sICH (P = .04). On multivariate analysis, good collateral flow (odds ratio [OR], 0.18; 95% confidence interval [CI], 0.04–0.75; P = .01) and age (OR, 1.08; 95% CI, 1.01–1.15; P = .01) were the only predictors of good outcome. The use of more than one device for thrombectomy was the only predictor of sICH (OR, 10.74; 95% CI, 1.37–84.13; P = .02). Conclusions Endovascular treatment for TO resulted in good outcomes. Collateral flow and age were independent predictors of good clinical outcomes at 3 months.

Original languageEnglish
Pages (from-to)543-549
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume28
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Sallustio, F., Motta, C., Koch, G., Pizzuto, S., Campbell, B. C. V., Diomedi, M., Rizzato, B., Davoli, A., Loreni, G., Konda, D., Stefanini, M., Fabiano, S., Pampana, E., Stanzione, P., & Gandini, R. (2017). Endovascular Stroke Treatment of Acute Tandem Occlusion: A Single-Center Experience. Journal of Vascular and Interventional Radiology, 28(4), 543-549. https://doi.org/10.1016/j.jvir.2017.01.007