Abstract
Background: A role for diet in laryngeal carcinogenesis has been suggested, but only a few studies have examined the potential relationship with a wide variety of macronutrients. Patients and methods: A case-control study was conducted between 1992 and 2000 in Italy and Switzerland, including 527 incident cases of laryngeal cancer, and 1297 controls hospitalized for acute, non-neoplastic conditions. The subjects' usual diet was investigated through a validated food frequency questionnaire, including 78 foods and beverages. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. Results: Cases reported higher energy intake than controls. The continuous OR for 100 kcal/day was 1.16 (95% CI 1.12-1.21) for alcohol energy, and 1.02 (95% CI 1.01-1.04) for non-alcohol energy. A significantly increased risk of laryngeal cancer was observed for animal protein (continuous OR = 1.21, 95% CI 1.03-1.41), polyunsaturated fats other than linoleic and linolenic fatty acids (OR = 1.43, 95% CI 1.19-1.70), and cholesterol intake (OR = 1.43, 95% CI 1.19-1.71). Laryngeal cancer risk was slightly reduced with increasing vegetable protein (OR = 0.75, 95% CI 0.62-0.91), sugar (OR = 0.84, 95% CI 0.71-1.00) and monounsaturated fatty acid intake (OR = 0.83, 95% CI 0.70-0.99). Conclusions: Laryngeal cancer cases have a higher energy intake than control subjects, and report a higher intake of animal protein and cholesterol.
| Original language | English |
|---|---|
| Pages (from-to) | 907-912 |
| Number of pages | 6 |
| Journal | Annals of Oncology |
| Volume | 14 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2003 |
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Keywords
- Case-control study
- Laryngeal cancer
- Nutrients
- Risk factors
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Energy, macronutrients and laryngeal cancer risk. / Bosetti, C.; La Vecchia, C.; Talamin, R.; Negri, E.; Levi, F.; Fryzek, J.; McLaughlin, J. K.; Garavello, W.; Franceschi, S.
In: Annals of Oncology, Vol. 14, No. 6, 01.06.2003, p. 907-912.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Energy, macronutrients and laryngeal cancer risk
AU - Bosetti, C.
AU - La Vecchia, C.
AU - Talamin, R.
AU - Negri, E.
AU - Levi, F.
AU - Fryzek, J.
AU - McLaughlin, J. K.
AU - Garavello, W.
AU - Franceschi, S.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Background: A role for diet in laryngeal carcinogenesis has been suggested, but only a few studies have examined the potential relationship with a wide variety of macronutrients. Patients and methods: A case-control study was conducted between 1992 and 2000 in Italy and Switzerland, including 527 incident cases of laryngeal cancer, and 1297 controls hospitalized for acute, non-neoplastic conditions. The subjects' usual diet was investigated through a validated food frequency questionnaire, including 78 foods and beverages. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. Results: Cases reported higher energy intake than controls. The continuous OR for 100 kcal/day was 1.16 (95% CI 1.12-1.21) for alcohol energy, and 1.02 (95% CI 1.01-1.04) for non-alcohol energy. A significantly increased risk of laryngeal cancer was observed for animal protein (continuous OR = 1.21, 95% CI 1.03-1.41), polyunsaturated fats other than linoleic and linolenic fatty acids (OR = 1.43, 95% CI 1.19-1.70), and cholesterol intake (OR = 1.43, 95% CI 1.19-1.71). Laryngeal cancer risk was slightly reduced with increasing vegetable protein (OR = 0.75, 95% CI 0.62-0.91), sugar (OR = 0.84, 95% CI 0.71-1.00) and monounsaturated fatty acid intake (OR = 0.83, 95% CI 0.70-0.99). Conclusions: Laryngeal cancer cases have a higher energy intake than control subjects, and report a higher intake of animal protein and cholesterol.
AB - Background: A role for diet in laryngeal carcinogenesis has been suggested, but only a few studies have examined the potential relationship with a wide variety of macronutrients. Patients and methods: A case-control study was conducted between 1992 and 2000 in Italy and Switzerland, including 527 incident cases of laryngeal cancer, and 1297 controls hospitalized for acute, non-neoplastic conditions. The subjects' usual diet was investigated through a validated food frequency questionnaire, including 78 foods and beverages. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. Results: Cases reported higher energy intake than controls. The continuous OR for 100 kcal/day was 1.16 (95% CI 1.12-1.21) for alcohol energy, and 1.02 (95% CI 1.01-1.04) for non-alcohol energy. A significantly increased risk of laryngeal cancer was observed for animal protein (continuous OR = 1.21, 95% CI 1.03-1.41), polyunsaturated fats other than linoleic and linolenic fatty acids (OR = 1.43, 95% CI 1.19-1.70), and cholesterol intake (OR = 1.43, 95% CI 1.19-1.71). Laryngeal cancer risk was slightly reduced with increasing vegetable protein (OR = 0.75, 95% CI 0.62-0.91), sugar (OR = 0.84, 95% CI 0.71-1.00) and monounsaturated fatty acid intake (OR = 0.83, 95% CI 0.70-0.99). Conclusions: Laryngeal cancer cases have a higher energy intake than control subjects, and report a higher intake of animal protein and cholesterol.
KW - Case-control study
KW - Laryngeal cancer
KW - Nutrients
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=0037673693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037673693&partnerID=8YFLogxK
U2 - 10.1093/annonc/mdg251
DO - 10.1093/annonc/mdg251
M3 - Article
VL - 14
SP - 907
EP - 912
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - 6
ER -