Energy, macronutrients and laryngeal cancer risk

C. Bosetti, C. La Vecchia, R. Talamin, E. Negri, F. Levi, J. Fryzek, J. K. McLaughlin, W. Garavello, S. Franceschi

Research output: Contribution to journalArticle

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Abstract

Background: A role for diet in laryngeal carcinogenesis has been suggested, but only a few studies have examined the potential relationship with a wide variety of macronutrients. Patients and methods: A case-control study was conducted between 1992 and 2000 in Italy and Switzerland, including 527 incident cases of laryngeal cancer, and 1297 controls hospitalized for acute, non-neoplastic conditions. The subjects' usual diet was investigated through a validated food frequency questionnaire, including 78 foods and beverages. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. Results: Cases reported higher energy intake than controls. The continuous OR for 100 kcal/day was 1.16 (95% CI 1.12-1.21) for alcohol energy, and 1.02 (95% CI 1.01-1.04) for non-alcohol energy. A significantly increased risk of laryngeal cancer was observed for animal protein (continuous OR = 1.21, 95% CI 1.03-1.41), polyunsaturated fats other than linoleic and linolenic fatty acids (OR = 1.43, 95% CI 1.19-1.70), and cholesterol intake (OR = 1.43, 95% CI 1.19-1.71). Laryngeal cancer risk was slightly reduced with increasing vegetable protein (OR = 0.75, 95% CI 0.62-0.91), sugar (OR = 0.84, 95% CI 0.71-1.00) and monounsaturated fatty acid intake (OR = 0.83, 95% CI 0.70-0.99). Conclusions: Laryngeal cancer cases have a higher energy intake than control subjects, and report a higher intake of animal protein and cholesterol.

Original languageEnglish
Pages (from-to)907-912
Number of pages6
JournalAnnals of Oncology
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

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Laryngeal Neoplasms
Confidence Intervals
Odds Ratio
Energy Intake
Logistic Models
Cholesterol
Linolenic Acids
Vegetable Proteins
Diet
Food and Beverages
Monounsaturated Fatty Acids
Switzerland
Italy
Case-Control Studies
Carcinogenesis
Proteins
Fats
Alcohols
Food

Keywords

  • Case-control study
  • Laryngeal cancer
  • Nutrients
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bosetti, C., La Vecchia, C., Talamin, R., Negri, E., Levi, F., Fryzek, J., ... Franceschi, S. (2003). Energy, macronutrients and laryngeal cancer risk. Annals of Oncology, 14(6), 907-912. https://doi.org/10.1093/annonc/mdg251

Energy, macronutrients and laryngeal cancer risk. / Bosetti, C.; La Vecchia, C.; Talamin, R.; Negri, E.; Levi, F.; Fryzek, J.; McLaughlin, J. K.; Garavello, W.; Franceschi, S.

In: Annals of Oncology, Vol. 14, No. 6, 01.06.2003, p. 907-912.

Research output: Contribution to journalArticle

Bosetti, C, La Vecchia, C, Talamin, R, Negri, E, Levi, F, Fryzek, J, McLaughlin, JK, Garavello, W & Franceschi, S 2003, 'Energy, macronutrients and laryngeal cancer risk', Annals of Oncology, vol. 14, no. 6, pp. 907-912. https://doi.org/10.1093/annonc/mdg251
Bosetti C, La Vecchia C, Talamin R, Negri E, Levi F, Fryzek J et al. Energy, macronutrients and laryngeal cancer risk. Annals of Oncology. 2003 Jun 1;14(6):907-912. https://doi.org/10.1093/annonc/mdg251
Bosetti, C. ; La Vecchia, C. ; Talamin, R. ; Negri, E. ; Levi, F. ; Fryzek, J. ; McLaughlin, J. K. ; Garavello, W. ; Franceschi, S. / Energy, macronutrients and laryngeal cancer risk. In: Annals of Oncology. 2003 ; Vol. 14, No. 6. pp. 907-912.
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abstract = "Background: A role for diet in laryngeal carcinogenesis has been suggested, but only a few studies have examined the potential relationship with a wide variety of macronutrients. Patients and methods: A case-control study was conducted between 1992 and 2000 in Italy and Switzerland, including 527 incident cases of laryngeal cancer, and 1297 controls hospitalized for acute, non-neoplastic conditions. The subjects' usual diet was investigated through a validated food frequency questionnaire, including 78 foods and beverages. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. Results: Cases reported higher energy intake than controls. The continuous OR for 100 kcal/day was 1.16 (95{\%} CI 1.12-1.21) for alcohol energy, and 1.02 (95{\%} CI 1.01-1.04) for non-alcohol energy. A significantly increased risk of laryngeal cancer was observed for animal protein (continuous OR = 1.21, 95{\%} CI 1.03-1.41), polyunsaturated fats other than linoleic and linolenic fatty acids (OR = 1.43, 95{\%} CI 1.19-1.70), and cholesterol intake (OR = 1.43, 95{\%} CI 1.19-1.71). Laryngeal cancer risk was slightly reduced with increasing vegetable protein (OR = 0.75, 95{\%} CI 0.62-0.91), sugar (OR = 0.84, 95{\%} CI 0.71-1.00) and monounsaturated fatty acid intake (OR = 0.83, 95{\%} CI 0.70-0.99). Conclusions: Laryngeal cancer cases have a higher energy intake than control subjects, and report a higher intake of animal protein and cholesterol.",
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AU - Talamin, R.

AU - Negri, E.

AU - Levi, F.

AU - Fryzek, J.

AU - McLaughlin, J. K.

AU - Garavello, W.

AU - Franceschi, S.

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N2 - Background: A role for diet in laryngeal carcinogenesis has been suggested, but only a few studies have examined the potential relationship with a wide variety of macronutrients. Patients and methods: A case-control study was conducted between 1992 and 2000 in Italy and Switzerland, including 527 incident cases of laryngeal cancer, and 1297 controls hospitalized for acute, non-neoplastic conditions. The subjects' usual diet was investigated through a validated food frequency questionnaire, including 78 foods and beverages. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. Results: Cases reported higher energy intake than controls. The continuous OR for 100 kcal/day was 1.16 (95% CI 1.12-1.21) for alcohol energy, and 1.02 (95% CI 1.01-1.04) for non-alcohol energy. A significantly increased risk of laryngeal cancer was observed for animal protein (continuous OR = 1.21, 95% CI 1.03-1.41), polyunsaturated fats other than linoleic and linolenic fatty acids (OR = 1.43, 95% CI 1.19-1.70), and cholesterol intake (OR = 1.43, 95% CI 1.19-1.71). Laryngeal cancer risk was slightly reduced with increasing vegetable protein (OR = 0.75, 95% CI 0.62-0.91), sugar (OR = 0.84, 95% CI 0.71-1.00) and monounsaturated fatty acid intake (OR = 0.83, 95% CI 0.70-0.99). Conclusions: Laryngeal cancer cases have a higher energy intake than control subjects, and report a higher intake of animal protein and cholesterol.

AB - Background: A role for diet in laryngeal carcinogenesis has been suggested, but only a few studies have examined the potential relationship with a wide variety of macronutrients. Patients and methods: A case-control study was conducted between 1992 and 2000 in Italy and Switzerland, including 527 incident cases of laryngeal cancer, and 1297 controls hospitalized for acute, non-neoplastic conditions. The subjects' usual diet was investigated through a validated food frequency questionnaire, including 78 foods and beverages. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. Results: Cases reported higher energy intake than controls. The continuous OR for 100 kcal/day was 1.16 (95% CI 1.12-1.21) for alcohol energy, and 1.02 (95% CI 1.01-1.04) for non-alcohol energy. A significantly increased risk of laryngeal cancer was observed for animal protein (continuous OR = 1.21, 95% CI 1.03-1.41), polyunsaturated fats other than linoleic and linolenic fatty acids (OR = 1.43, 95% CI 1.19-1.70), and cholesterol intake (OR = 1.43, 95% CI 1.19-1.71). Laryngeal cancer risk was slightly reduced with increasing vegetable protein (OR = 0.75, 95% CI 0.62-0.91), sugar (OR = 0.84, 95% CI 0.71-1.00) and monounsaturated fatty acid intake (OR = 0.83, 95% CI 0.70-0.99). Conclusions: Laryngeal cancer cases have a higher energy intake than control subjects, and report a higher intake of animal protein and cholesterol.

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