Energy metabolism of normal and lonidamine-treated sertoli cells of rats

A. Floridi, M. L. Marcante, S. D'Atri, R. Feriozzi, R. Menichini, G. Citro, V. Cioli, C. De Martino

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of lonidamine on oxygen consumption, aerobic lactate production, and [U-14C]glucose metabolism of rat Sertoli cells was investigated. The results may be summarized as follows: (1) Sertoli cells show well-developed energy metabolism both in vitro and in vivo. (2) The rate of aerobic lactate production is markedly higher than in other cell types, either normal differentiated or neoplastic, such as Ehrlich ascites tumor cells. (3) Lonidamine does not affect respiration and aerobic glycolysis of Sertoli cells. This finding is consistent with previous data which demonstrated that the antispermatogenic effect can be mainly ascribed to an irreversible alteration of germ cell mitochondria induced by 1-substituted indazole-3-carboxylic acids of which lonidamine represents one of the most potent derivatives. (4) The functional impairment induced by lonidamine on rat Sertoli cells cannot be ascribed to an action on the energy metabolism even if, up to date, the biochemical target is still unclear.

Original languageEnglish
Pages (from-to)137-147
Number of pages11
JournalExperimental and Molecular Pathology
Volume38
Issue number1
DOIs
Publication statusPublished - 1983

Fingerprint

Sertoli Cells
Energy Metabolism
Rats
Cells
Antispermatogenic Agents
Lactic Acid
Ehrlich Tumor Carcinoma
Mitochondria
Glycolysis
Metabolism
Germ Cells
Oxygen Consumption
Tumors
Respiration
Oxygen
Derivatives
Glucose
lonidamine

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Floridi, A., Marcante, M. L., D'Atri, S., Feriozzi, R., Menichini, R., Citro, G., ... De Martino, C. (1983). Energy metabolism of normal and lonidamine-treated sertoli cells of rats. Experimental and Molecular Pathology, 38(1), 137-147. https://doi.org/10.1016/0014-4800(83)90105-3

Energy metabolism of normal and lonidamine-treated sertoli cells of rats. / Floridi, A.; Marcante, M. L.; D'Atri, S.; Feriozzi, R.; Menichini, R.; Citro, G.; Cioli, V.; De Martino, C.

In: Experimental and Molecular Pathology, Vol. 38, No. 1, 1983, p. 137-147.

Research output: Contribution to journalArticle

Floridi, A, Marcante, ML, D'Atri, S, Feriozzi, R, Menichini, R, Citro, G, Cioli, V & De Martino, C 1983, 'Energy metabolism of normal and lonidamine-treated sertoli cells of rats', Experimental and Molecular Pathology, vol. 38, no. 1, pp. 137-147. https://doi.org/10.1016/0014-4800(83)90105-3
Floridi, A. ; Marcante, M. L. ; D'Atri, S. ; Feriozzi, R. ; Menichini, R. ; Citro, G. ; Cioli, V. ; De Martino, C. / Energy metabolism of normal and lonidamine-treated sertoli cells of rats. In: Experimental and Molecular Pathology. 1983 ; Vol. 38, No. 1. pp. 137-147.
@article{23ff2e805e2f40899c0e0ed33bb775b5,
title = "Energy metabolism of normal and lonidamine-treated sertoli cells of rats",
abstract = "The effect of lonidamine on oxygen consumption, aerobic lactate production, and [U-14C]glucose metabolism of rat Sertoli cells was investigated. The results may be summarized as follows: (1) Sertoli cells show well-developed energy metabolism both in vitro and in vivo. (2) The rate of aerobic lactate production is markedly higher than in other cell types, either normal differentiated or neoplastic, such as Ehrlich ascites tumor cells. (3) Lonidamine does not affect respiration and aerobic glycolysis of Sertoli cells. This finding is consistent with previous data which demonstrated that the antispermatogenic effect can be mainly ascribed to an irreversible alteration of germ cell mitochondria induced by 1-substituted indazole-3-carboxylic acids of which lonidamine represents one of the most potent derivatives. (4) The functional impairment induced by lonidamine on rat Sertoli cells cannot be ascribed to an action on the energy metabolism even if, up to date, the biochemical target is still unclear.",
author = "A. Floridi and Marcante, {M. L.} and S. D'Atri and R. Feriozzi and R. Menichini and G. Citro and V. Cioli and {De Martino}, C.",
year = "1983",
doi = "10.1016/0014-4800(83)90105-3",
language = "English",
volume = "38",
pages = "137--147",
journal = "Experimental and Molecular Pathology",
issn = "0014-4800",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Energy metabolism of normal and lonidamine-treated sertoli cells of rats

AU - Floridi, A.

AU - Marcante, M. L.

AU - D'Atri, S.

AU - Feriozzi, R.

AU - Menichini, R.

AU - Citro, G.

AU - Cioli, V.

AU - De Martino, C.

PY - 1983

Y1 - 1983

N2 - The effect of lonidamine on oxygen consumption, aerobic lactate production, and [U-14C]glucose metabolism of rat Sertoli cells was investigated. The results may be summarized as follows: (1) Sertoli cells show well-developed energy metabolism both in vitro and in vivo. (2) The rate of aerobic lactate production is markedly higher than in other cell types, either normal differentiated or neoplastic, such as Ehrlich ascites tumor cells. (3) Lonidamine does not affect respiration and aerobic glycolysis of Sertoli cells. This finding is consistent with previous data which demonstrated that the antispermatogenic effect can be mainly ascribed to an irreversible alteration of germ cell mitochondria induced by 1-substituted indazole-3-carboxylic acids of which lonidamine represents one of the most potent derivatives. (4) The functional impairment induced by lonidamine on rat Sertoli cells cannot be ascribed to an action on the energy metabolism even if, up to date, the biochemical target is still unclear.

AB - The effect of lonidamine on oxygen consumption, aerobic lactate production, and [U-14C]glucose metabolism of rat Sertoli cells was investigated. The results may be summarized as follows: (1) Sertoli cells show well-developed energy metabolism both in vitro and in vivo. (2) The rate of aerobic lactate production is markedly higher than in other cell types, either normal differentiated or neoplastic, such as Ehrlich ascites tumor cells. (3) Lonidamine does not affect respiration and aerobic glycolysis of Sertoli cells. This finding is consistent with previous data which demonstrated that the antispermatogenic effect can be mainly ascribed to an irreversible alteration of germ cell mitochondria induced by 1-substituted indazole-3-carboxylic acids of which lonidamine represents one of the most potent derivatives. (4) The functional impairment induced by lonidamine on rat Sertoli cells cannot be ascribed to an action on the energy metabolism even if, up to date, the biochemical target is still unclear.

UR - http://www.scopus.com/inward/record.url?scp=0020681897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020681897&partnerID=8YFLogxK

U2 - 10.1016/0014-4800(83)90105-3

DO - 10.1016/0014-4800(83)90105-3

M3 - Article

VL - 38

SP - 137

EP - 147

JO - Experimental and Molecular Pathology

JF - Experimental and Molecular Pathology

SN - 0014-4800

IS - 1

ER -