Engineered membranes improve cardiac function in ischemic rat hearts

Monica Sandri, Anna Tampieri, Joung H Levialdi Ghiron, Gianluigi Condorelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the relatively young field of cardiac tissue engineering, different biomaterials, methods and techniques have been tested for cardiac repair. In this study we examined the validity of a series of new preformed membrane scaffolds, based on collagen type I, for the transplantation of cardiac cells. One type of membrane, cross-linked with 1, 4-butanediol diglycidyl ether (BDDGE) and fibronectin-enriched, gave rise to spontaneously beating heart cell constructs 5-9 days after seeding with neonatal rat cardiac cells. This membrane was then grafted, with and without beating cardiac cells, onto the infarcted area of rat models of heart failure. Seriate echocardiography, performed on rats before transplantation and at 4 and 8 weeks after transplantation, showed that rats that received collagen membranes with beating cells showed an improvement in cardiac function after 8 weeks. These results suggest that this new type of collagen membrane can be used as vector for the transplantation of beating heart cells to the injured myocardium, hence representing an important potential tool for cardiac tissue repair technologies.

Original languageEnglish
Title of host publicationASME 2010 5th Frontiers in Biomedical Devices Conference and Exhibition, BIOMED 2010
Pages95-98
Number of pages4
DOIs
Publication statusPublished - 2010
EventASME 2010 5th Frontiers in Biomedical Devices Conference and Exhibition, BIOMED 2010 - Newport Beach, CA, United States
Duration: Sep 20 2010Sep 21 2010

Other

OtherASME 2010 5th Frontiers in Biomedical Devices Conference and Exhibition, BIOMED 2010
CountryUnited States
CityNewport Beach, CA
Period9/20/109/21/10

Keywords

  • Biocompatibility
  • Cardiac tissue engineering
  • Collagen
  • Scaffold

ASJC Scopus subject areas

  • Biomedical Engineering

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  • Cite this

    Sandri, M., Tampieri, A., Ghiron, J. H. L., & Condorelli, G. (2010). Engineered membranes improve cardiac function in ischemic rat hearts. In ASME 2010 5th Frontiers in Biomedical Devices Conference and Exhibition, BIOMED 2010 (pp. 95-98) https://doi.org/10.1115/BioMed2010-32060