An immunosuppressive tumor microenvironment is a cancer hallmark and a major impediment to successful immunotherapy. We engineered hematopoietic progenitors to target expression of an interferon-α (IFNα) transgene specifically to their monocytic progeny, including tumor-infiltrating macrophages. Mice chimeric for these IFNα-expressing macrophages showed activation of innate and adaptive immune cells against breast cancer and inhibited disease progression.
- Breast cancer
- Gene transfer strategy
- IFN-α delivery
- Immunosuppressive microenvironment
- Tumour associated macrophages
ASJC Scopus subject areas
- Immunology and Allergy