Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression

Giulia Escobar, Bernhard Gentner, Luigi Naldini, Roberta Mazzieri

Research output: Contribution to journalArticlepeer-review

Abstract

An immunosuppressive tumor microenvironment is a cancer hallmark and a major impediment to successful immunotherapy. We engineered hematopoietic progenitors to target expression of an interferon-α (IFNα) transgene specifically to their monocytic progeny, including tumor-infiltrating macrophages. Mice chimeric for these IFNα-expressing macrophages showed activation of innate and adaptive immune cells against breast cancer and inhibited disease progression.

Original languageEnglish
Article numbere28696
JournalOncoImmunology
Volume3
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Breast cancer
  • Gene transfer strategy
  • IFN-α delivery
  • Immunosuppressive microenvironment
  • Tumour associated macrophages

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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