Enhanced BDNF serum levels in patients with severe pathological gambling

Francesco Angelucci; Giovanni Martinotti; Francesca Gelfo; Elisabetta Righino; Gianluigi Conte; Carlo Caltagirone; Pietro Bria; Valerio Ricci

doi:10.1111/j.1369-1600.2011.00411.x

Enhanced BDNF serum levels in patients with severe pathological gambling

Francesco Angelucci, Giovanni Martinotti, Francesca Gelfo, Elisabetta Righino, Gianluigi Conte, Carlo Caltagirone, Pietro Bria, Valerio Ricci

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Although the pathophysiology of gambling is unknown, an involvement of midbrain dopaminergic pathway has been hypothesized. In this study, the association between brain-derived neurotrophic factor (BDNF) and pathological gambling was investigated. We measured BDNF serum levels in (1) video players (n = 10); (2) card players (n = 9); (3) mixed players (n = 21; both video and card players) and (4) age-matched controls (n = 18). Mixed players had increased BDNF serum levels as compared to controls and higher South Oaks Gambling Screen score as compared to card or video players. Thus, the data demonstrate that patients affected by severe pathological gambling show enhanced BDNF serum levels.

Original language	English
Pages (from-to)	749-751
Number of pages	3
Journal	Addiction Biology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1111/j.1369-1600.2011.00411.x
Publication status	Published - Jul 2013

Keywords

BDNF
dopamine
ELISA
pathological gambling
serum levels
SOGS

ASJC Scopus subject areas

Medicine (miscellaneous)
Psychiatry and Mental health
Pharmacology

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AU - Angelucci, Francesco

AU - Martinotti, Giovanni

AU - Gelfo, Francesca

AU - Righino, Elisabetta

AU - Conte, Gianluigi

AU - Caltagirone, Carlo

AU - Bria, Pietro

AU - Ricci, Valerio

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