Abstract
SV40 transformants of human embryo fibroblasts showed an enhanced chemotactic response to fibronectin and conditioned medium of fibroblasts in comparison to the non-transformed cells. An even higher chemotatic response was characteristic for a malignant human fibrosarcoma cell line, whereas cells derived from low-grade malignant dermatofibrosarcoma showed a normal response in the Boyden chamber assay. The high stimulation of chemotaxis is paralelled by a reduced synthesis and an altered deposition of fibronectin in the pericellular matrix of these cells. Both high chemotactic response and lack of deposition of fibronectin may play a role in tissue invasion and formation of metastasis by malignant tumors.
Original language | English |
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Pages (from-to) | 43-48 |
Number of pages | 6 |
Journal | International Journal of Cancer |
Volume | 33 |
Issue number | 1 |
Publication status | Published - 1984 |
ASJC Scopus subject areas
- Cancer Research
- Oncology