Enhanced chemotaxis of tumor-derived and virus-transformed cells to fibronectin and fibroblast-conditioned medium

H. Mensing, A. Albini, T. Krieg, B. F. Pontz, P. K. Müller

Research output: Contribution to journalArticlepeer-review

Abstract

SV40 transformants of human embryo fibroblasts showed an enhanced chemotactic response to fibronectin and conditioned medium of fibroblasts in comparison to the non-transformed cells. An even higher chemotatic response was characteristic for a malignant human fibrosarcoma cell line, whereas cells derived from low-grade malignant dermatofibrosarcoma showed a normal response in the Boyden chamber assay. The high stimulation of chemotaxis is paralelled by a reduced synthesis and an altered deposition of fibronectin in the pericellular matrix of these cells. Both high chemotactic response and lack of deposition of fibronectin may play a role in tissue invasion and formation of metastasis by malignant tumors.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalInternational Journal of Cancer
Volume33
Issue number1
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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