Abstract
In cancer therapy, it is imperative to increase the efficacy and reduce side effects of chemotherapeutic drugs. Nanotechnology offers the unique opportunity to overcome these barriers. In particular, in the last few years, DNA nanostructures have gained attention for their biocompatibility, easy customized synthesis and ability to deliver drugs to cancer cells. Here, an open-caged pyramidal DNA at Doxorubicin (Py-Doxo) nanostructure was constructed with 10 DNA sequences of 26-28 nucleotides for drug delivery to cancer cells. The synthesized DNA nanostructures are sufficiently stable in biological medium. Py-Doxo exhibited significantly enhanced cytotoxicity of the delivered doxorubicin to breast and liver cancer cells up to twofold compared to free doxorubicin. This study demonstrates the importance of the shape and structure of the designed transporter DNA nanostructures for biomedical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 106-110 |
| Number of pages | 5 |
| Journal | Journal of Cellular Physiology |
| Volume | 231 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Cell Biology
- Physiology
- Medicine(all)
Cite this
Enhanced Chemotherapeutic Behavior of Open-Caged DNA at Doxorubicin Nanostructures for Cancer Cells. / Kumar, Vinit; Bayda, Samer; Hadla, Mohamad; Caligiuri, Isabella; Russo Spena, Concetta; Palazzolo, Stefano; Kempter, Susanne; Corona, Giuseppe; Toffoli, Giuseppe; Rizzolio, Flavio.
In: Journal of Cellular Physiology, Vol. 231, No. 1, 01.01.2016, p. 106-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhanced Chemotherapeutic Behavior of Open-Caged DNA at Doxorubicin Nanostructures for Cancer Cells
AU - Kumar, Vinit
AU - Bayda, Samer
AU - Hadla, Mohamad
AU - Caligiuri, Isabella
AU - Russo Spena, Concetta
AU - Palazzolo, Stefano
AU - Kempter, Susanne
AU - Corona, Giuseppe
AU - Toffoli, Giuseppe
AU - Rizzolio, Flavio
PY - 2016/1/1
Y1 - 2016/1/1
N2 - In cancer therapy, it is imperative to increase the efficacy and reduce side effects of chemotherapeutic drugs. Nanotechnology offers the unique opportunity to overcome these barriers. In particular, in the last few years, DNA nanostructures have gained attention for their biocompatibility, easy customized synthesis and ability to deliver drugs to cancer cells. Here, an open-caged pyramidal DNA at Doxorubicin (Py-Doxo) nanostructure was constructed with 10 DNA sequences of 26-28 nucleotides for drug delivery to cancer cells. The synthesized DNA nanostructures are sufficiently stable in biological medium. Py-Doxo exhibited significantly enhanced cytotoxicity of the delivered doxorubicin to breast and liver cancer cells up to twofold compared to free doxorubicin. This study demonstrates the importance of the shape and structure of the designed transporter DNA nanostructures for biomedical applications.
AB - In cancer therapy, it is imperative to increase the efficacy and reduce side effects of chemotherapeutic drugs. Nanotechnology offers the unique opportunity to overcome these barriers. In particular, in the last few years, DNA nanostructures have gained attention for their biocompatibility, easy customized synthesis and ability to deliver drugs to cancer cells. Here, an open-caged pyramidal DNA at Doxorubicin (Py-Doxo) nanostructure was constructed with 10 DNA sequences of 26-28 nucleotides for drug delivery to cancer cells. The synthesized DNA nanostructures are sufficiently stable in biological medium. Py-Doxo exhibited significantly enhanced cytotoxicity of the delivered doxorubicin to breast and liver cancer cells up to twofold compared to free doxorubicin. This study demonstrates the importance of the shape and structure of the designed transporter DNA nanostructures for biomedical applications.
UR - http://www.scopus.com/inward/record.url?scp=84942342255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942342255&partnerID=8YFLogxK
U2 - 10.1002/jcp.25057
DO - 10.1002/jcp.25057
M3 - Article
VL - 231
SP - 106
EP - 110
JO - Journal of cellular and comparative physiology
JF - Journal of cellular and comparative physiology
SN - 0021-9541
IS - 1
ER -