Enhanced chromosomal fragility in neuroblastoma: Correlation with poor prognosis

P. Vernole, B. Tedeschi, G. Melino, C. Pianca, B. Nicoletti

Research output: Contribution to journalArticlepeer-review


In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lympocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin and a variety of personal and clinical characteristics were verified. Patients with a poor prognosis generally proved to be more susceptible to fragile site induction.

Original languageEnglish
Pages (from-to)1419-1421
Number of pages3
JournalAnticancer Research
Issue number5
Publication statusPublished - 1992


  • Chromosomal fragility
  • Common fragile sites
  • Neuroblastoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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