Enhanced erythroid burst formation in mice after testosterone treatment

Cesare Peschle; Maria Cristina Magli; Clemente Cillo; Federico Lettieri; Francesco Pizzella; Arturo Genovese; Andrea Soricelli

doi:10.1016/0024-3205(77)90404-0

Enhanced erythroid burst formation in mice after testosterone treatment

Cesare Peschle, Maria Cristina Magli, Clemente Cillo, Federico Lettieri, Francesco Pizzella, Arturo Genovese, Andrea Soricelli

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Abstract

A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36-49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.

Original language	English
Pages (from-to)	773-778
Number of pages	6
Journal	Life Sciences
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/0024-3205(77)90404-0
Publication status	Published - Sep 15 1977

ASJC Scopus subject areas

Pharmacology

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Peschle, C., Magli, M. C., Cillo, C., Lettieri, F., Pizzella, F., Genovese, A., & Soricelli, A. (1977). Enhanced erythroid burst formation in mice after testosterone treatment. Life Sciences, 21(6), 773-778. https://doi.org/10.1016/0024-3205(77)90404-0

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title = "Enhanced erythroid burst formation in mice after testosterone treatment",

abstract = "A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36-49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.",

author = "Cesare Peschle and Magli, {Maria Cristina} and Clemente Cillo and Federico Lettieri and Francesco Pizzella and Arturo Genovese and Andrea Soricelli",

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T1 - Enhanced erythroid burst formation in mice after testosterone treatment

AU - Peschle, Cesare

AU - Magli, Maria Cristina

AU - Cillo, Clemente

AU - Lettieri, Federico

AU - Pizzella, Francesco

AU - Genovese, Arturo

AU - Soricelli, Andrea

PY - 1977/9/15

Y1 - 1977/9/15

N2 - A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36-49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.

AB - A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36-49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.

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