Enhanced erythroid burst formation in mice after testosterone treatment

Cesare Peschle, Maria Cristina Magli, Clemente Cillo, Federico Lettieri, Francesco Pizzella, Arturo Genovese, Andrea Soricelli

Research output: Contribution to journalArticlepeer-review

Abstract

A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36-49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.

Original languageEnglish
Pages (from-to)773-778
Number of pages6
JournalLife Sciences
Volume21
Issue number6
DOIs
Publication statusPublished - Sep 15 1977

ASJC Scopus subject areas

  • Pharmacology

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