Enhanced erythroid burst formation in mice after testosterone treatment

Cesare Peschle, Maria Cristina Magli, Clemente Cillo, Federico Lettieri, Francesco Pizzella, Arturo Genovese, Andrea Soricelli

Research output: Contribution to journalArticle

Abstract

A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36-49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.

Original languageEnglish
Pages (from-to)773-778
Number of pages6
JournalLife Sciences
Volume21
Issue number6
DOIs
Publication statusPublished - Sep 15 1977

Fingerprint

Erythroid Precursor Cells
Amplification
Testosterone
Testosterone Propionate
Erythropoietin
Stem cells
Androgens
Stem Cells
Hand
Bone Marrow
Serum

ASJC Scopus subject areas

  • Pharmacology

Cite this

Peschle, C., Magli, M. C., Cillo, C., Lettieri, F., Pizzella, F., Genovese, A., & Soricelli, A. (1977). Enhanced erythroid burst formation in mice after testosterone treatment. Life Sciences, 21(6), 773-778. https://doi.org/10.1016/0024-3205(77)90404-0

Enhanced erythroid burst formation in mice after testosterone treatment. / Peschle, Cesare; Magli, Maria Cristina; Cillo, Clemente; Lettieri, Federico; Pizzella, Francesco; Genovese, Arturo; Soricelli, Andrea.

In: Life Sciences, Vol. 21, No. 6, 15.09.1977, p. 773-778.

Research output: Contribution to journalArticle

Peschle, C, Magli, MC, Cillo, C, Lettieri, F, Pizzella, F, Genovese, A & Soricelli, A 1977, 'Enhanced erythroid burst formation in mice after testosterone treatment', Life Sciences, vol. 21, no. 6, pp. 773-778. https://doi.org/10.1016/0024-3205(77)90404-0
Peschle C, Magli MC, Cillo C, Lettieri F, Pizzella F, Genovese A et al. Enhanced erythroid burst formation in mice after testosterone treatment. Life Sciences. 1977 Sep 15;21(6):773-778. https://doi.org/10.1016/0024-3205(77)90404-0
Peschle, Cesare ; Magli, Maria Cristina ; Cillo, Clemente ; Lettieri, Federico ; Pizzella, Francesco ; Genovese, Arturo ; Soricelli, Andrea. / Enhanced erythroid burst formation in mice after testosterone treatment. In: Life Sciences. 1977 ; Vol. 21, No. 6. pp. 773-778.
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