Abstract
A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36-49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.
| Original language | English |
|---|---|
| Pages (from-to) | 773-778 |
| Number of pages | 6 |
| Journal | Life Sciences |
| Volume | 21 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Sep 15 1977 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Enhanced erythroid burst formation in mice after testosterone treatment. / Peschle, Cesare; Magli, Maria Cristina; Cillo, Clemente; Lettieri, Federico; Pizzella, Francesco; Genovese, Arturo; Soricelli, Andrea.
In: Life Sciences, Vol. 21, No. 6, 15.09.1977, p. 773-778.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhanced erythroid burst formation in mice after testosterone treatment
AU - Peschle, Cesare
AU - Magli, Maria Cristina
AU - Cillo, Clemente
AU - Lettieri, Federico
AU - Pizzella, Francesco
AU - Genovese, Arturo
AU - Soricelli, Andrea
PY - 1977/9/15
Y1 - 1977/9/15
N2 - A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36-49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.
AB - A single administration of testosterone propionate (TP) in ex-hypoxic polycythemic mice induces, at 24 hr after androgen, an amplification of the erythroid burst-forming unit (BFU-E or B) pool in marrow. This phenomenon is not associated with an amplification of the erythroid colony-forming unit (CFU-E or E) compartment and is followed by its depletion. In the other hand, the 36-49 hr rise of erythropoietin (Ep) levels in serum is followed by a 60-hr amplification of the E pool. It is suggested that the latter phenomenon is mediated by enhanced Ep production, whereas the early amplification of the B compartment may derive from a direct influence of TP at the stem cell level.
UR - http://www.scopus.com/inward/record.url?scp=0017666886&partnerID=8YFLogxK
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U2 - 10.1016/0024-3205(77)90404-0
DO - 10.1016/0024-3205(77)90404-0
M3 - Article
C2 - 916799
AN - SCOPUS:0017666886
VL - 21
SP - 773
EP - 778
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 6
ER -