Enhanced in vitro culture of human SAOS-2 osteoblasts on a sand-blasted titanium surface modified with plastic deformation.

Lorenzo Fassina, Enrica Saino, Livia Visai, Maria G. De Angelis, Francesco Benazzo, Giovanni Magenes

Research output: Contribution to journalArticle

Abstract

The titanium surfaces with micro-roughness have been studied to substitute machined titanium, with the focus on enhancing the bone apposition onto the implant. In this study we have followed a biomimetic strategy where human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a sandblasted titanium surface modified with plastic deformation. In comparison with sandblasted titanium surface, the plastic deformation increased the cell proliferation and the surface coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.

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Osteoblasts
Titanium
Cell culture
Plastics
Plastic deformation
Sand
Bone
Bone and Bones
Biomimetics
Bone Matrix
Cell proliferation
Biocompatible Materials
Biomaterials
Extracellular Matrix
Repair
Surface roughness
Cell Proliferation
Coatings
In Vitro Techniques

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

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title = "Enhanced in vitro culture of human SAOS-2 osteoblasts on a sand-blasted titanium surface modified with plastic deformation.",
abstract = "The titanium surfaces with micro-roughness have been studied to substitute machined titanium, with the focus on enhancing the bone apposition onto the implant. In this study we have followed a biomimetic strategy where human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a sandblasted titanium surface modified with plastic deformation. In comparison with sandblasted titanium surface, the plastic deformation increased the cell proliferation and the surface coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.",
author = "Lorenzo Fassina and Enrica Saino and Livia Visai and {De Angelis}, {Maria G.} and Francesco Benazzo and Giovanni Magenes",
year = "2007",
language = "English",
pages = "6411--6414",
journal = "Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference",
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AU - Fassina, Lorenzo

AU - Saino, Enrica

AU - Visai, Livia

AU - De Angelis, Maria G.

AU - Benazzo, Francesco

AU - Magenes, Giovanni

PY - 2007

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AB - The titanium surfaces with micro-roughness have been studied to substitute machined titanium, with the focus on enhancing the bone apposition onto the implant. In this study we have followed a biomimetic strategy where human SAOS-2 osteoblasts proliferated and built their extracellular matrix on a sandblasted titanium surface modified with plastic deformation. In comparison with sandblasted titanium surface, the plastic deformation increased the cell proliferation and the surface coating with bone matrix. The superficially modified biomaterial could be used, in clinical applications, as an implant for bone repair.

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