Enhanced in vitro testing model for rapid risk assessment of ingested nanomaterials

Catherine Carnovale, Daniela Guarnieri, Isabella De Angelis, Flavia Barone, Stefania Sabella

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Increased nanomaterial use and production has raised concerns about health hazards which may result from their intentional or incidental ingestion. While various in vitro assays are employed to assess the behaviour of manufactured nanomaterials following ingestion, most lack consideration for key factors which are necessary to mimic realistic exposure conditions. By linking two validated processes - a simulated dynamic gastrointestinal digestion model and an intestinal barrier integrity assay, we are able to recreate a likely intake scenario of chronic nanoparticle exposure over a prolonged period. Results indicate that the test is robust, providing reproducible results for a range of nanomaterials. Further the process can be used to determined if a read across approach for risk assessment of manufactured nanomaterials can be logically applied. This study highlights the significance a complete lifecycle analysis for nanomaterials which includes assessing their stability and behaviour within different biological matrices.

Original languageEnglish
Title of host publicationAdvanced Materials - TechConnect Briefs 2017
PublisherTechConnect
Pages317-320
Number of pages4
Volume1
ISBN (Electronic)9780997511789
Publication statusPublished - Jan 1 2017
Event11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference - Washington, United States
Duration: May 14 2017May 17 2017

Conference

Conference11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference
CountryUnited States
CityWashington
Period5/14/175/17/17

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Keywords

  • Digestion
  • Manufactured nanomaterials
  • Nanotoxicology
  • Read across
  • Risk assessment

ASJC Scopus subject areas

  • Fuel Technology
  • Surfaces, Coatings and Films
  • Biotechnology
  • Fluid Flow and Transfer Processes

Cite this

Carnovale, C., Guarnieri, D., De Angelis, I., Barone, F., & Sabella, S. (2017). Enhanced in vitro testing model for rapid risk assessment of ingested nanomaterials. In Advanced Materials - TechConnect Briefs 2017 (Vol. 1, pp. 317-320). TechConnect.