Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina

Giovanna Liuzzo, Antonino Buffon, Luigi M. Biasucci, J. Ruth Gallimore, Giuseppina Caligiuri, Alessandra Vitelli, Sergio Altamura, Gennaro Ciliberto, Antonio G. Rebuzzi, Filippo Crea, Mark B. Pepys, Attilio Maseri

Research output: Contribution to journalArticlepeer-review

Abstract

Background-Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleukin-6 (IL-6) after single-vessel PTCA in 30 patients with stable and 56 patients with unstable angina (protocol A). We also studied 12 patients with stable and 15 with unstable angina after diagnostic coronary angiography (protocol B). Methods and Results-Peripheral blood samples were taken before and 6, 24, 48, and 72 hours after PTCA or angiography. In protocol A, baseline CRP, SAA, and IL-6 levels were normal in 87% of stable and 29% of unstable patients. After PTCA, CRP, SAA, and IL-6 did not change in stable patients and unstable patients with normal baseline levels but increased in unstable patients with raised baseline levels (all P

Original languageEnglish
Pages (from-to)2370-2376
Number of pages7
JournalCirculation
Volume98
Issue number22
Publication statusPublished - Dec 1 1998

Keywords

  • Angina
  • Angioplasty
  • Interleukins
  • Plaque

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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