Enhanced interleukin-1β in hypercholesterolemia: Effects of simvastatin and low-dose aspirin

Patrizia Ferroni, Francesca Martini, Cristiano M. Cardarello, Pier Paolo Gazzaniga, Giovanni Davì, Stefania Basili

Research output: Contribution to journalArticle

Abstract

Background - This study was aimed at verifying whether activation of platelets might represent a source of interleukin (IL)-1β levels in hypercholesterolemia. To this purpose, we compared the effects of a short-term treatment with simvastatin or low-dose aspirin on circulating levels of this cytokine. Methods and Results - Fifty patients with hypercholesterolemia were randomly allocated to receive an 8-week therapeutic course of simvastatin 20 mg daily (n=25) or aspirin 100 mg daily (n=25). Baseline soluble (s) P-selectin directly correlated with IL-1β (P

Original languageEnglish
Pages (from-to)1673-1675
Number of pages3
JournalCirculation
Volume108
Issue number14
DOIs
Publication statusPublished - Oct 7 2003

Keywords

  • Aspirin
  • Hypercholesterolemia
  • Inflammation
  • Platelets
  • Statins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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