Enhanced interleukin-1β in hypercholesterolemia: Effects of simvastatin and low-dose aspirin

Patrizia Ferroni, Francesca Martini, Cristiano M. Cardarello, Pier Paolo Gazzaniga, Giovanni Davì, Stefania Basili

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background - This study was aimed at verifying whether activation of platelets might represent a source of interleukin (IL)-1β levels in hypercholesterolemia. To this purpose, we compared the effects of a short-term treatment with simvastatin or low-dose aspirin on circulating levels of this cytokine. Methods and Results - Fifty patients with hypercholesterolemia were randomly allocated to receive an 8-week therapeutic course of simvastatin 20 mg daily (n=25) or aspirin 100 mg daily (n=25). Baseline soluble (s) P-selectin directly correlated with IL-1β (P

Original languageEnglish
Pages (from-to)1673-1675
Number of pages3
JournalCirculation
Volume108
Issue number14
DOIs
Publication statusPublished - Oct 7 2003

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Simvastatin
Hypercholesterolemia
Interleukin-1
Aspirin
P-Selectin
Platelet Activation
Cytokines
Therapeutics

Keywords

  • Aspirin
  • Hypercholesterolemia
  • Inflammation
  • Platelets
  • Statins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Enhanced interleukin-1β in hypercholesterolemia : Effects of simvastatin and low-dose aspirin. / Ferroni, Patrizia; Martini, Francesca; Cardarello, Cristiano M.; Gazzaniga, Pier Paolo; Davì, Giovanni; Basili, Stefania.

In: Circulation, Vol. 108, No. 14, 07.10.2003, p. 1673-1675.

Research output: Contribution to journalArticle

Ferroni, P, Martini, F, Cardarello, CM, Gazzaniga, PP, Davì, G & Basili, S 2003, 'Enhanced interleukin-1β in hypercholesterolemia: Effects of simvastatin and low-dose aspirin', Circulation, vol. 108, no. 14, pp. 1673-1675. https://doi.org/10.1161/01.CIR.0000094732.02060.27
Ferroni, Patrizia ; Martini, Francesca ; Cardarello, Cristiano M. ; Gazzaniga, Pier Paolo ; Davì, Giovanni ; Basili, Stefania. / Enhanced interleukin-1β in hypercholesterolemia : Effects of simvastatin and low-dose aspirin. In: Circulation. 2003 ; Vol. 108, No. 14. pp. 1673-1675.
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