Enhanced percentage of CD5+ B lymphocytes in newly diagnosed IDDM patients

F. Nicoletti, P. L. Meroni, W. Barcellini, P. Steinsväg, M. Di Mauro, M. Lunetta, M. Pagano, U. Consoli, C. Zanussi

Research output: Contribution to journalArticlepeer-review


The percentage of CD5+ B lymphocytes, the prevalence of islet cell antibodies (ICA) and of anti-insulin autoantibodies (IAA) and HLA-A-B-C and DR antigens were studied in 32 newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients, in 12 non-insulin-dependent diabetes mellitus (NIDDM) patients and in 12 healthy subjects. The percentage of CD5+ B lymphocytes ranged from 18% to 51.2% (mean 40.3±11%) in IDDM patients, whereas in NIDDM patients and in controls it ranged from 20% to 25.2%, (mean 21.3±4.1%) and from 16% to 24%, (mean 19.3±1.9%), respectively (P

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalImmunology Letters
Issue number3
Publication statusPublished - 1990


  • Anti-insulin autoantibody
  • CD5+ B lymphocyte
  • Insulin-dependent diabetes mellitus
  • Islet cell antibody

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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