Enhanced peripheral vasoconstrictor response and increased thromboxane A2 synthesis after the cold pressor test in patients with angina at rest

G. G N Serneri, G. F. Gensini, G. Masotti

Research output: Contribution to journalArticle

Abstract

Peripheral vascular resistance (PVR) and thromboxane A2 (TxA2) synthesis after the cold pressor test were investigated in different subsets of patients with angina (10 with stable effort angina, 36 with resting angina [24 in an active phase and 12 in an inactive phase], and five with Prinzmetal's variant angina) and in 41 control subjects of equivalent age and risk factors. Left ventricular end-diastolic pressure, ejection fraction, extent of coronary angiographic lesions, and baseline PVR were not significantly different among the various patient groups. In all patient groups, except those with variant angina, the cold pressor test resulted in a higher increase in PVR than in the control subjects (p <.001 for all groups). In patients with variant angina the vasoconstrictor response was increased only in proximity (about 1 hr) to ischemic attacks. In patients with active resting angina the vasoconstrictor response was on the average four times longer than that in patients with effort angina and with inactive resting angina (p <.001). This exaggerated vasoconstrictor response was associated with elevated TxA2 resting levels in plasma and with increased TxA2 synthesis after the cold pressor test. A linear relationship was found between the area of the vascular response and the area of TxA2 production after the cold pressor test in patients with active resting angina (r = .87, p <.001). The increased TxA2 synthesis and the inappropriate increase of peripheral vascular response to sympathetic stimulation revert back to normal in the inactive phase. These alterations might contribute to the occurrence of inappropriate vasoconstriction and of the abnormal vascular responsiveness to various stimuli frequently found in patients with unstable angina.

Original languageEnglish
Pages (from-to)409-417
Number of pages9
JournalCirculation
Volume73
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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