Enhanced portal flow velocity and volume following Iloprost treatment

Enrico Maria Zardi, Antonio Picardi, Giovanni Ambrosino, Vito Michele Fazio, Aldo Dobrina, Antonella Afeltra, Mauro Frego

Research output: Contribution to journalArticle

Abstract

Objective: We studied, with color Doppler sonography, portal flow velocity (PV) and volume (PFV) before and after Iloprost infusion. Background: Iloprost is a prostacyclin analogue with arterial vasodilator and platelet aggregation inhibitor properties. Recently, hemodynamic effects after treatment with Iloprost have been demonstrated in subjects with arteriopathy of lower limbs. Methods: We treated 10 subjects (2 males and 8 females; mean age 64±8.2 years) affected by arteriopathy of lower limbs with intravenous infusion of Iloprost, at a dosage of 2 ng/Kg/min (16 hours/day) for 3 days. In all patients portal vein flow velocity (PV) (cm/s) and volume (PFV) (ml/min) were assessed. PV was directly determined by the Doppler system, whereas PFV was calculated using the formula "CSA × PV", after measuring the portal vein cross sectional area (CSA) (mm2). Results: The patients showed markedly increased PV and PFV after Iloprost infusion (pre-Iloprost vs post-Iloprost treatment mean portal flow velocity and volume values: 23.12±3.89 cm/s vs 28.49±3.90 cm/s, p

Original languageEnglish
Pages (from-to)108-110
Number of pages3
JournalActa Biomedica
Volume74
Issue numberSUPPL. 2
Publication statusPublished - 2003

Fingerprint

Iloprost
Portal Vein
Therapeutics
Lower Extremity
Doppler Color Ultrasonography
Platelet Aggregation Inhibitors
Epoprostenol
Vasodilator Agents
Intravenous Infusions
Hemodynamics

Keywords

  • Color Doppler ultrasound
  • Hepatic circulation
  • Iloprost
  • Liver transplantion
  • Portal flow velocity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zardi, E. M., Picardi, A., Ambrosino, G., Fazio, V. M., Dobrina, A., Afeltra, A., & Frego, M. (2003). Enhanced portal flow velocity and volume following Iloprost treatment. Acta Biomedica, 74(SUPPL. 2), 108-110.

Enhanced portal flow velocity and volume following Iloprost treatment. / Zardi, Enrico Maria; Picardi, Antonio; Ambrosino, Giovanni; Fazio, Vito Michele; Dobrina, Aldo; Afeltra, Antonella; Frego, Mauro.

In: Acta Biomedica, Vol. 74, No. SUPPL. 2, 2003, p. 108-110.

Research output: Contribution to journalArticle

Zardi, EM, Picardi, A, Ambrosino, G, Fazio, VM, Dobrina, A, Afeltra, A & Frego, M 2003, 'Enhanced portal flow velocity and volume following Iloprost treatment', Acta Biomedica, vol. 74, no. SUPPL. 2, pp. 108-110.
Zardi EM, Picardi A, Ambrosino G, Fazio VM, Dobrina A, Afeltra A et al. Enhanced portal flow velocity and volume following Iloprost treatment. Acta Biomedica. 2003;74(SUPPL. 2):108-110.
Zardi, Enrico Maria ; Picardi, Antonio ; Ambrosino, Giovanni ; Fazio, Vito Michele ; Dobrina, Aldo ; Afeltra, Antonella ; Frego, Mauro. / Enhanced portal flow velocity and volume following Iloprost treatment. In: Acta Biomedica. 2003 ; Vol. 74, No. SUPPL. 2. pp. 108-110.
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