Enhanced portal flow velocity and volume following Iloprost treatment

Enrico Maria Zardi, Antonio Picardi, Giovanni Ambrosino, Vito Michele Fazio, Aldo Dobrina, Antonella Afeltra, Mauro Frego

Research output: Contribution to journalArticlepeer-review


Objective: We studied, with color Doppler sonography, portal flow velocity (PV) and volume (PFV) before and after Iloprost infusion. Background: Iloprost is a prostacyclin analogue with arterial vasodilator and platelet aggregation inhibitor properties. Recently, hemodynamic effects after treatment with Iloprost have been demonstrated in subjects with arteriopathy of lower limbs. Methods: We treated 10 subjects (2 males and 8 females; mean age 64±8.2 years) affected by arteriopathy of lower limbs with intravenous infusion of Iloprost, at a dosage of 2 ng/Kg/min (16 hours/day) for 3 days. In all patients portal vein flow velocity (PV) (cm/s) and volume (PFV) (ml/min) were assessed. PV was directly determined by the Doppler system, whereas PFV was calculated using the formula "CSA × PV", after measuring the portal vein cross sectional area (CSA) (mm2). Results: The patients showed markedly increased PV and PFV after Iloprost infusion (pre-Iloprost vs post-Iloprost treatment mean portal flow velocity and volume values: 23.12±3.89 cm/s vs 28.49±3.90 cm/s, p

Original languageEnglish
Pages (from-to)108-110
Number of pages3
JournalActa Biomedica
Issue numberSUPPL. 2
Publication statusPublished - 2003


  • Color Doppler ultrasound
  • Hepatic circulation
  • Iloprost
  • Liver transplantion
  • Portal flow velocity

ASJC Scopus subject areas

  • Medicine(all)


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