Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers

Pietro Ghezzi, Marina Bianchi, Alberto Mantovani, Federico Spreafico, Mario Salmona

Research output: Contribution to journalArticlepeer-review

Abstract

Administration to mice of either interferon (IFN) or IFN inducers resulted in a marked increase of xanthine oxidase (XO) activity in different organs. Dose response studies revealed that serum XO was increased by administration of polyinosylic-polycyticylic acid (poly I-C) at doses as low as 0.1 mg/kg. In view of the well known ability of XO to generate superoxide radicals it is suggested that its induction might play a role in several biological effects of IFN.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume119
Issue number1
DOIs
Publication statusPublished - Feb 29 1984

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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