Abstract
Cultured human endothelial cells produce increased levels of PA-I when stimulated with IL-1. The stimulatory effect was elicited by both alfa (pI 5) and beta (pI 7) IL-1 molecules. The effect was both dose and time-dependent, plateau reached after 8 h. The PA-I measured in cell extracts was SDS-resistant with an apparent m.w. of 53 Kd and inhibited both tissue-type plasminogen activator (t-PA) and urokinase (UK). No change in t-PA antigen level was detected with any of the IL-1 preparations tested.
Original language | English |
---|---|
Pages (from-to) | 720-727 |
Number of pages | 8 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 139 |
Issue number | 2 |
DOIs | |
Publication status | Published - Sep 16 1986 |
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology