Enhancement by nifedipine of cholinergic-induced depression of locomotor activity in mice

M. Sansone, M. Battaglia, F. Pavone

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The dihydropyridine calcium channel blocker nifedipine did not affect spontaneous locomotor activity in mice when given alone but enhanced the depressant effects of the muscarinic receptor agonist oxotremorine and of the acetylcholinesterase inhibitor physostigmine. Such a behavioral depression might be due to neuronal changes induced by central calcium channel blockade combined with cholinergic activation. However, an involvement of hemodynamic factors, related to peripheral vasodilatation, cannot be excluded as locomotor depressant effects were also exerted by combinations of the two cholinomimetic agents with hydralazine, a non-calcium antagonist vasodilator.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalFunctional Neurology
Volume10
Issue number4-5
Publication statusPublished - 1995

Fingerprint

Locomotion
Nifedipine
Cholinergic Agents
Oxotremorine
Muscarinic Agonists
Hydralazine
Physostigmine
Cholinesterase Inhibitors
Calcium Channel Blockers
Muscarinic Receptors
Calcium Channels
Vasodilator Agents
Vasodilation
Hemodynamics
1,4-dihydropyridine

Keywords

  • Locomotor activity
  • Mice
  • Nifedipine
  • Oxotremorine
  • Physostigmine

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Enhancement by nifedipine of cholinergic-induced depression of locomotor activity in mice. / Sansone, M.; Battaglia, M.; Pavone, F.

In: Functional Neurology, Vol. 10, No. 4-5, 1995, p. 163-167.

Research output: Contribution to journalArticle

Sansone, M, Battaglia, M & Pavone, F 1995, 'Enhancement by nifedipine of cholinergic-induced depression of locomotor activity in mice', Functional Neurology, vol. 10, no. 4-5, pp. 163-167.
Sansone, M. ; Battaglia, M. ; Pavone, F. / Enhancement by nifedipine of cholinergic-induced depression of locomotor activity in mice. In: Functional Neurology. 1995 ; Vol. 10, No. 4-5. pp. 163-167.
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