Enhancement by nifedipine of cholinergic-induced depression of locomotor activity in mice

M. Sansone, M. Battaglia, F. Pavone

Research output: Contribution to journalArticlepeer-review

Abstract

The dihydropyridine calcium channel blocker nifedipine did not affect spontaneous locomotor activity in mice when given alone but enhanced the depressant effects of the muscarinic receptor agonist oxotremorine and of the acetylcholinesterase inhibitor physostigmine. Such a behavioral depression might be due to neuronal changes induced by central calcium channel blockade combined with cholinergic activation. However, an involvement of hemodynamic factors, related to peripheral vasodilatation, cannot be excluded as locomotor depressant effects were also exerted by combinations of the two cholinomimetic agents with hydralazine, a non-calcium antagonist vasodilator.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalFunctional Neurology
Volume10
Issue number4-5
Publication statusPublished - 1995

Keywords

  • Locomotor activity
  • Mice
  • Nifedipine
  • Oxotremorine
  • Physostigmine

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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