Abstract
We studied the ability of TP-1, a calf thymic extract, to influence in vitro pokeweed mitogen (PWM)-induced plasma cell generation and blastogenesis of peripheral blood lymphocytes from normal donors and from patients with systemic lupus erythematosus (SLE). In normal subjects, TP-1 significantly increased plasma cell generation, but did not affect the mitogenic response to PWM. On the contrary, differentiation of B cells from SLE patients was not enhanced by this extract. The action on the differentiation of normal B cells could either be due to a direct effect on B cells or be mediated by activation of helper T cells.
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Thymus |
| Volume | 4 |
| Issue number | 1 |
| Publication status | Published - 1982 |
Fingerprint
ASJC Scopus subject areas
- Immunology
Cite this
Fiorilli, M., Sirianni, M. C., Pandolfi, F., Pucillo, L. P., Letta, T., & Aiuti, F. (1982). Enhancement by TP-1, a thymic extract, of pokeweed mitogen-induced differentiation of B cells from normal subjects but not of those from patients with systemic lupus erythematosus. Thymus, 4(1), 1-7.