Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells

Marella Maroder; Alessandra Vacca; Isabella Screpanti; Elisa Petrangeli; Luigi Frati; Alberto Gulino

doi:10.1016/0167-4781(89)90100-0

Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells

Marella Maroder, Alessandra Vacca, Isabella Screpanti, Elisa Petrangeli, Luigi Frati, Alberto Gulino

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Abstract

The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.

Original language	English
Pages (from-to)	188-190
Number of pages	3
Journal	BBA - Gene Structure and Expression
Volume	1009
Issue number	2
DOIs	https://doi.org/10.1016/0167-4781(89)90100-0
Publication status	Published - Nov 2 1989

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Keywords

c-erbA
Cell profiteration
Glucosteroid
Human lymphoid cell)
Proto-oncogene expression

ASJC Scopus subject areas

Biochemistry
Biophysics
Genetics
Structural Biology

Cite this

Maroder, M., Vacca, A., Screpanti, I., Petrangeli, E., Frati, L., & Gulino, A. (1989). Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells. BBA - Gene Structure and Expression, 1009(2), 188-190. https://doi.org/10.1016/0167-4781(89)90100-0

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abstract = "The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.",

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AU - Petrangeli, Elisa

AU - Frati, Luigi

AU - Gulino, Alberto

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10.1016/0167-4781(89)90100-0