Abstract
The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.
Original language | English |
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Pages (from-to) | 188-190 |
Number of pages | 3 |
Journal | BBA - Gene Structure and Expression |
Volume | 1009 |
Issue number | 2 |
DOIs | |
Publication status | Published - Nov 2 1989 |
Keywords
- c-erbA
- Cell profiteration
- Glucosteroid
- Human lymphoid cell)
- Proto-oncogene expression
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Genetics
- Structural Biology