Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells

Marella Maroder, Alessandra Vacca, Isabella Screpanti, Elisa Petrangeli, Luigi Frati, Alberto Gulino

Research output: Contribution to journalArticle

Abstract

The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.

Original languageEnglish
Pages (from-to)188-190
Number of pages3
JournalBBA - Gene Structure and Expression
Volume1009
Issue number2
DOIs
Publication statusPublished - Nov 2 1989

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Keywords

  • c-erbA
  • Cell profiteration
  • Glucosteroid
  • Human lymphoid cell)
  • Proto-oncogene expression

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics
  • Structural Biology

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