Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells

Marella Maroder, Alessandra Vacca, Isabella Screpanti, Elisa Petrangeli, Luigi Frati, Alberto Gulino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.

Original languageEnglish
Pages (from-to)188-190
Number of pages3
JournalBBA - Gene Structure and Expression
Volume1009
Issue number2
DOIs
Publication statusPublished - Nov 2 1989

Fingerprint

erbA Genes
Dexamethasone
Glucocorticoids
Lymphoma
Hormones
Messenger RNA
Cell proliferation
Cell Proliferation
Proto-Oncogenes
Cell growth
Cycloheximide
Oncogenes
Lymphocytes
RNA
Growth
Proteins

Keywords

  • c-erbA
  • Cell profiteration
  • Glucosteroid
  • Human lymphoid cell)
  • Proto-oncogene expression

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics
  • Structural Biology

Cite this

Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells. / Maroder, Marella; Vacca, Alessandra; Screpanti, Isabella; Petrangeli, Elisa; Frati, Luigi; Gulino, Alberto.

In: BBA - Gene Structure and Expression, Vol. 1009, No. 2, 02.11.1989, p. 188-190.

Research output: Contribution to journalArticle

Maroder, Marella ; Vacca, Alessandra ; Screpanti, Isabella ; Petrangeli, Elisa ; Frati, Luigi ; Gulino, Alberto. / Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells. In: BBA - Gene Structure and Expression. 1989 ; Vol. 1009, No. 2. pp. 188-190.
@article{4e5f021a717d48dcba2906275a6e5ed9,
title = "Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells",
abstract = "The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.",
keywords = "c-erbA, Cell profiteration, Glucosteroid, Human lymphoid cell), Proto-oncogene expression",
author = "Marella Maroder and Alessandra Vacca and Isabella Screpanti and Elisa Petrangeli and Luigi Frati and Alberto Gulino",
year = "1989",
month = "11",
day = "2",
doi = "10.1016/0167-4781(89)90100-0",
language = "English",
volume = "1009",
pages = "188--190",
journal = "Biochimica et Biophysica Acta - Gene Structure and Expression",
issn = "0167-4781",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells

AU - Maroder, Marella

AU - Vacca, Alessandra

AU - Screpanti, Isabella

AU - Petrangeli, Elisa

AU - Frati, Luigi

AU - Gulino, Alberto

PY - 1989/11/2

Y1 - 1989/11/2

N2 - The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.

AB - The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.

KW - c-erbA

KW - Cell profiteration

KW - Glucosteroid

KW - Human lymphoid cell)

KW - Proto-oncogene expression

UR - http://www.scopus.com/inward/record.url?scp=0024422826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024422826&partnerID=8YFLogxK

U2 - 10.1016/0167-4781(89)90100-0

DO - 10.1016/0167-4781(89)90100-0

M3 - Article

C2 - 2553102

AN - SCOPUS:0024422826

VL - 1009

SP - 188

EP - 190

JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

SN - 0167-4781

IS - 2

ER -