Abstract
The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.
| Original language | English |
|---|---|
| Pages (from-to) | 188-190 |
| Number of pages | 3 |
| Journal | BBA - Gene Structure and Expression |
| Volume | 1009 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 2 1989 |
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Keywords
- c-erbA
- Cell profiteration
- Glucosteroid
- Human lymphoid cell)
- Proto-oncogene expression
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Genetics
- Structural Biology
Cite this
Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells. / Maroder, Marella; Vacca, Alessandra; Screpanti, Isabella; Petrangeli, Elisa; Frati, Luigi; Gulino, Alberto.
In: BBA - Gene Structure and Expression, Vol. 1009, No. 2, 02.11.1989, p. 188-190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhancement of c-erbA proto-oncogene expression by glucocorticoid hormones in S49.1 lymphoma cells
AU - Maroder, Marella
AU - Vacca, Alessandra
AU - Screpanti, Isabella
AU - Petrangeli, Elisa
AU - Frati, Luigi
AU - Gulino, Alberto
PY - 1989/11/2
Y1 - 1989/11/2
N2 - The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.
AB - The modification of the mRNA levels of the c-myc and c-erbA proto-oncogenes during the dexamethasone-induced decrease of S49.1 cell proliferation have been studied. The levels of c-myc mRNA decreased significantly between 3 and 18 h after dexamethaxone (1 μM) treatment. In contrast, a significant increase in the levels of a 2.6 kb c-erbA mRNA was observed between 6 and 18 h hormone treatment.Cycloheximide treatment of S49.1 cells increased the levels of c-erbA RNA and overcome the enhancing effect of dexamethasone on the expression of this proto-oncogene, suggesting that ongoing protein synthesis is necessary to elicit this hormone effect. The associated decrease of cell proliferation and changes in c-myc and c-erbA mRNA levels after dexamethasone treatment suggest that such oncogenes might be involved in the dexamethasone-mediated control of lymphoid cell growth.
KW - c-erbA
KW - Cell profiteration
KW - Glucosteroid
KW - Human lymphoid cell)
KW - Proto-oncogene expression
UR - http://www.scopus.com/inward/record.url?scp=0024422826&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024422826&partnerID=8YFLogxK
U2 - 10.1016/0167-4781(89)90100-0
DO - 10.1016/0167-4781(89)90100-0
M3 - Article
C2 - 2553102
AN - SCOPUS:0024422826
VL - 1009
SP - 188
EP - 190
JO - Biochimica et Biophysica Acta - Gene Structure and Expression
JF - Biochimica et Biophysica Acta - Gene Structure and Expression
SN - 0167-4781
IS - 2
ER -