Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma

P. L. Lollini, C. De Giovanni, G. Nicoletti, A. Bontadini, P. L. Tazzari, L. Landuzzi, K. Scotlandi, P. Nanni

Research output: Contribution to journalArticle


The effects of recombinant tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on B16 mouse melanoma experimental metastatic ability and major histocompatibility complex (H-2b) antigens expression were studied. B16 cells exposed in vitro to TNF-alpha had an increased H-2 expression and were more metastatic than untreated cells. The simultaneous treatment with TNF-alpha and IFN-gamma amplified the enhancement of experimental metastasis and all other effects obtained with TNF-alpha alone. The B16 clone B78H1, selectively resistant to H-2 induction and to enhancement of metastatic ability by IFN-gamma, was not affected by treatment with TNF-alpha and with TNF-alpha + IFN-gamma. These findings contribute to a better understanding of the pleiotropic effects of TNF, some of which can have opposing actions in the complex tumor-host relationships.[/p]

Original languageEnglish
Pages (from-to)215-224
Number of pages10
JournalClinical & Experimental Metastasis
Issue number2
Publication statusPublished - Mar 1990


ASJC Scopus subject areas

  • Cancer Research

Cite this