Enhancement of motor cortical excitability in humans by non-invasive electrical stimulation appears prior to voluntary movement

A. Starr, M. Caramia, F. Zarola, P. M. Rossini

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

The time course of facilitation of motor evoked potentials (MEPs) to transcranial electrical stimulation delivered at varying intervals near the onset of a voluntary ballistic movement was studied in 4 normal subjects. MEPs were recorded from the left thenar muscles to unifocal anodal stimulation of the right scalp overlying the hand motor area delivered every 8-10 sec. A click, occasionally associated with the scalp stimulation (P = 0.3-0.6), was the signal for the subject to make a brief thumb press on a piston at short latency. The timing of the scalp stimulus and the click was adjusted so that the former occurred approximately between 100 msec before and 100 msec after the onset of the voluntary movement signaled by the EMG in the thenar muscles. MEPs were not detected when the scalp was stimulated 80 msec or more before onset of voluntary movement and then appeared with increasing probability as the time interval before movement shortened. The amplitudes of MEPs in the 80-40 msec period preceding movement onset were small (<20% of maximum) and achieved maximum values 20 msec after movement onset.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalElectroencephalography and Clinical Neurophysiology
Volume70
Issue number1
DOIs
Publication statusPublished - 1988

Fingerprint

Motor Evoked Potentials
Scalp
Electric Stimulation
Muscles
Thumb
Motor Cortex
Hand
Cortical Excitability

Keywords

  • (Human)
  • Motor cortex excitability
  • Non-invasive electrical stimulation
  • Voluntary movement

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

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abstract = "The time course of facilitation of motor evoked potentials (MEPs) to transcranial electrical stimulation delivered at varying intervals near the onset of a voluntary ballistic movement was studied in 4 normal subjects. MEPs were recorded from the left thenar muscles to unifocal anodal stimulation of the right scalp overlying the hand motor area delivered every 8-10 sec. A click, occasionally associated with the scalp stimulation (P = 0.3-0.6), was the signal for the subject to make a brief thumb press on a piston at short latency. The timing of the scalp stimulus and the click was adjusted so that the former occurred approximately between 100 msec before and 100 msec after the onset of the voluntary movement signaled by the EMG in the thenar muscles. MEPs were not detected when the scalp was stimulated 80 msec or more before onset of voluntary movement and then appeared with increasing probability as the time interval before movement shortened. The amplitudes of MEPs in the 80-40 msec period preceding movement onset were small (<20{\%} of maximum) and achieved maximum values 20 msec after movement onset.",
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AU - Caramia, M.

AU - Zarola, F.

AU - Rossini, P. M.

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N2 - The time course of facilitation of motor evoked potentials (MEPs) to transcranial electrical stimulation delivered at varying intervals near the onset of a voluntary ballistic movement was studied in 4 normal subjects. MEPs were recorded from the left thenar muscles to unifocal anodal stimulation of the right scalp overlying the hand motor area delivered every 8-10 sec. A click, occasionally associated with the scalp stimulation (P = 0.3-0.6), was the signal for the subject to make a brief thumb press on a piston at short latency. The timing of the scalp stimulus and the click was adjusted so that the former occurred approximately between 100 msec before and 100 msec after the onset of the voluntary movement signaled by the EMG in the thenar muscles. MEPs were not detected when the scalp was stimulated 80 msec or more before onset of voluntary movement and then appeared with increasing probability as the time interval before movement shortened. The amplitudes of MEPs in the 80-40 msec period preceding movement onset were small (<20% of maximum) and achieved maximum values 20 msec after movement onset.

AB - The time course of facilitation of motor evoked potentials (MEPs) to transcranial electrical stimulation delivered at varying intervals near the onset of a voluntary ballistic movement was studied in 4 normal subjects. MEPs were recorded from the left thenar muscles to unifocal anodal stimulation of the right scalp overlying the hand motor area delivered every 8-10 sec. A click, occasionally associated with the scalp stimulation (P = 0.3-0.6), was the signal for the subject to make a brief thumb press on a piston at short latency. The timing of the scalp stimulus and the click was adjusted so that the former occurred approximately between 100 msec before and 100 msec after the onset of the voluntary movement signaled by the EMG in the thenar muscles. MEPs were not detected when the scalp was stimulated 80 msec or more before onset of voluntary movement and then appeared with increasing probability as the time interval before movement shortened. The amplitudes of MEPs in the 80-40 msec period preceding movement onset were small (<20% of maximum) and achieved maximum values 20 msec after movement onset.

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