Enhancement of natural killer cell activity in mice by treatment with a thymic factor

Francesco Bistoni, Manuela Baccarini, Paolo Puccetti, Pierfrancesco Marconi, Enrico Garaci

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Abstract

The administration of a thymic factor, thymostimulin (TP-1), to mice resulted in considerable augmentation of natural killer (NK) cell activity as measured in a short-term assay against 51Cr-labeled YAC-1 target cells. Conditions suitable for detection of the thymostimulin-induced boosting of NK included multiple daily exposures to TP-1 (50 μg/kg), and peak levels of reactivity were observed at 2-4 days after discontinuation of treatment. A strict age-dependency of the effect was also observed, with optimal augmentation of NK-cell activity when TP-1 was administered to mice at 4-6 weeks of age. The effect was not limited to TP-1 treatment but was also observed on administration of another thymic factor (thymosin α1). The activated cells responsible for the increased natural cell-mediated cytotoxicity appeared to be typical murine NK cells, judging by both functional and antigenic criteria.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalCancer Immunology, Immunotherapy
Volume17
Issue number1
DOIs
Publication statusPublished - Jun 1984

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Natural Killer Cells
Thymosin
thymostimulin

ASJC Scopus subject areas

  • Oncology
  • Immunology
  • Cancer Research

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Enhancement of natural killer cell activity in mice by treatment with a thymic factor. / Bistoni, Francesco; Baccarini, Manuela; Puccetti, Paolo; Marconi, Pierfrancesco; Garaci, Enrico.

In: Cancer Immunology, Immunotherapy, Vol. 17, No. 1, 06.1984, p. 51-55.

Research output: Contribution to journalArticle

Bistoni, Francesco ; Baccarini, Manuela ; Puccetti, Paolo ; Marconi, Pierfrancesco ; Garaci, Enrico. / Enhancement of natural killer cell activity in mice by treatment with a thymic factor. In: Cancer Immunology, Immunotherapy. 1984 ; Vol. 17, No. 1. pp. 51-55.
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