To evaluate the hypothesis that cyclic AMP is involved in the regulation of plasminogen activator level in plasma, the effect of exogenous cyclic AMP and of its dibutyryl derivative; of glucagon, lysine vasopressin and adrenaline (activators of adenyl cyclase) have been investigated in human volunteers on their intravenous infusion. Cyclic AMP, dibutyryl cyclic AMP and glucagon had no effect on plasminogen activator. The marked rise induced by adrenaline and lysine vasopressin was not potentiated by the simultaneous administration of theophylline, an inhibitor of phosphodiesterase. These results do not support the hypothesis that cyclic AMP is the final common pathway for the effect on plasminogen activator induced by lysine vasopressin and adrenaline. There is also at present no conclusive evidence that cyclic AMP is involved as a physiologic regulator of the fibrinolytic system.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine