Enhancement of rotavirus infectivity by saturated fatty acids

Fabiana Superti, Maria Luisa Marziano, Gianfranco Donelli, Magda Marchetti, Lucilla Seganti

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of different saturated fatty acids from 10 to 16 carbon atom chains and some derivatives on the infectivity of SA-11 rotavirus was examined. Both fatty acids and derivatives induced an increase of rotavirus infected LLC-MK2 cells when present during viral absorption to host cells. Capric acid and palmitic acid were the most effective with a dose-dependent relationship. These last lipids, in the same experimental conditions, failed to restore the susceptibility to infection of LLC-MK2 cells made resistant by neuraminidase treatment or to allow cell infection by non-infectious single-shelled viral particles. Results obtained suggest that the enhancing effect on viral infectivity by saturated fatty acids requires previous binding of rotaviral outer capsid proteins to sialic acid containing cell receptors.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalComparative Immunology, Microbiology and Infectious Diseases
Volume18
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • fatty acids
  • Rotavirus

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Immunology and Allergy
  • Infectious Diseases
  • veterinary(all)
  • Animal Science and Zoology

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