Enhancement versus tumor resistance induced by different levels of immunodepression in BALB/c mice with protozoan infections

Santo Landolfo, Mirella Giovarelli, Maria Giovanna Martinotti, Luigi Varesio, Piero Cappuccinelli

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between the growth pattern of a spontaneous syngeneic adenocarcinoma and the immunodepression state caused by Trichomonas vaginalis and Trypanosoma congolense infection was evaluated in syngeneic BALB/c mice. We show that in T. vaginalis infected mice a slight and transient depression of both humoral and cellular immune reactivity induces an enhanced tumor growth. By contrast, a marked and long lasting depression of both humoral and cellular immune reactivity in mice infected with T. congolense occurs together with a delay in tumor take and a slower tumor growth. The various parameters affecting tumor growth in protozoan infected mice are discussed.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalEuropean Journal of Cancer (1965)
Volume15
Issue number1
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Oncology

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