The relationship between the growth pattern of a spontaneous syngeneic adenocarcinoma and the immunodepression state caused by Trichomonas vaginalis and Trypanosoma congolense infection was evaluated in syngeneic BALB/c mice. We show that in T. vaginalis infected mice a slight and transient depression of both humoral and cellular immune reactivity induces an enhanced tumor growth. By contrast, a marked and long lasting depression of both humoral and cellular immune reactivity in mice infected with T. congolense occurs together with a delay in tumor take and a slower tumor growth. The various parameters affecting tumor growth in protozoan infected mice are discussed.
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