Enhancing the biological activity of polyoxometalate-peptide nano-fibrils by spacer design.

Valeria Tagliavini; Claudia Honisch; Simona Serratì; Amalia Azzariti; Marcella Bonchio; Paolo Ruzza; Mauro Carraro

doi:10.1039/d0ra10218k

Enhancing the biological activity of polyoxometalate-peptide nano-fibrils by spacer design.

Valeria Tagliavini, Claudia Honisch, Simona Serratì, Amalia Azzariti, Marcella Bonchio, Paolo Ruzza, Mauro Carraro

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson-Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability. This journal is

Original language	English
Pages (from-to)	4952-4957
Number of pages	6
Journal	RSC Advances
Volume	11
Issue number	9
DOIs	https://doi.org/10.1039/d0ra10218k
Publication status	Published - Jan 26 2021

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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AU - Tagliavini, Valeria

AU - Honisch, Claudia

AU - Serratì, Simona

AU - Azzariti, Amalia

AU - Bonchio, Marcella

AU - Ruzza, Paolo

AU - Carraro, Mauro

PY - 2021/1/26

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AB - Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson-Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability. This journal is

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Enhancing the biological activity of polyoxometalate-peptide nano-fibrils by spacer design.

Abstract

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