Enhancing the biological activity of polyoxometalate-peptide nano-fibrils by spacer design.

Valeria Tagliavini, Claudia Honisch, Simona Serratì, Amalia Azzariti, Marcella Bonchio, Paolo Ruzza, Mauro Carraro

Research output: Contribution to journalArticlepeer-review

Abstract

Polyoxometalates (POMs) and peptides can be conjugated to yield novel bio-hybrids with potential application as nanodrugs. However, the observed POM-induced folding of the peptide prevents its availability towards biological targets. An Anderson-Evans POM was functionalized with a bombesin analog peptide and engineered by adding a tailored hydrophilic and anionic spacer between the two moieties, to make the targeting sequence more accessible and enable an unprecedented cancer cell recognition capability. This journal is

Original languageEnglish
Pages (from-to)4952-4957
Number of pages6
JournalRSC Advances
Volume11
Issue number9
DOIs
Publication statusPublished - Jan 26 2021

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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