Entacapone reduces cortical activation in Parkinson's disease with wearing-off: A f-MRI study

Nicola Tambasco, Marco Muti, Pietro Chiarini, Roberto Tarducci, Stefano Caproni, Anna Castrioto, Pasquale Nigro, Lucilla Parnetti, Pietro Floridi, Aroldo Rossi, Paolo Calabresi

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Wearing-off is one of the most frequent problems encountered by levodopa-treated patients. Entacapone, a peripheral inhibitor of catechol-O-methyltransferase (COMT), reduces this motor complication by prolonging the effect of levodopa. We sought to understand the impact of COMT-inhibition on movement execution in PD patients with wearing-off by comparing functional magnetic resonance imaging (f-MRI) activation patterns prior to and during entacapone treatment. Our hypothesis was to determine whether changes in cortical activation are associated to COMT-inhibitor treatment. Methods: Nine levodopa-treated non-demented PD patients with wearing-off were prospectively studied in two f-MRI session, prior to and during entacapone treatment. A group of control subjects were also studied for comparison. Results: The patients significantly improved under COMT-inhibitor treatment based on home diaries. F-MRI results showed that at baseline the patients presented a bilateral activation of the primary motor, controlateral premotor cortex and supplementary motor area, as well as ipsilateral cerebellum. During treatment with entacapone, PD patients showed reductions in the activations of these cortical areas and a decreased activation in the ipsilateral cerebellum. Conclusions: Our preliminary findings indicate that f-MRI is able to detect cortical activation changes during long-term modulation of dopaminergic treatment in PD patients with wearing-off, and thus, this technique could be further investigated in advanced PD patients.

Original languageEnglish
Article numbere96806
JournalPLoS One
Volume9
Issue number5
DOIs
Publication statusPublished - May 15 2014

    Fingerprint

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Tambasco, N., Muti, M., Chiarini, P., Tarducci, R., Caproni, S., Castrioto, A., Nigro, P., Parnetti, L., Floridi, P., Rossi, A., & Calabresi, P. (2014). Entacapone reduces cortical activation in Parkinson's disease with wearing-off: A f-MRI study. PLoS One, 9(5), [e96806]. https://doi.org/10.1371/journal.pone.0096806