Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: An international multicenter cohort study

Jorg Petersen, Vlad Ratziu, Maria Buti, Harry L A Janssen, Ashley Brown, Pietro Lampertico, Jan Schollmeyer, Fabien Zoulim, Heiner Wedemeyer, Martina Sterneck, Thomas Berg, Christoph Sarrazin, Marc Lutgehetmann, Peter Buggisch

Research output: Contribution to journalArticle

Abstract

Background & Aims: Long-term viral suppression is a major goal to prevent disease progression in patients with HBV. Aim of this study was to investigate the efficacy and safety of entecavir plus tenofovir combination in 57 CHB partial responders or multidrug resistant patients. Methods: Investigator-initiated open-label cohort study. Quantitative HBV-DNA measurement and resistance testing (line-probe-assays and direct-sequencing) at baseline and every 3 months. Results: Fifty seven patients (37 HBeAg+), median age 45 years, previously treated with a median of three lines of antiviral therapy (range 1-6), 24/57 with advanced liver disease, were included. Median ALT at baseline was 1.0 ULN (range 0.3-22) and HBV-DNA 1.5 × 10 4 IU/ml (range 500-1 × 10 11 IU/ml). Median treatment duration of combination therapy was 21 months. HBV-DNA level dropped 3 logs (median, range 0-8 log; p

Original languageEnglish
Pages (from-to)520-526
Number of pages7
JournalJournal of Hepatology
Volume56
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Clinical study
  • Combination therapy
  • Drug resistance
  • Entecavir
  • Hepatitis b
  • Tenofovir

ASJC Scopus subject areas

  • Hepatology

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    Petersen, J., Ratziu, V., Buti, M., Janssen, H. L. A., Brown, A., Lampertico, P., Schollmeyer, J., Zoulim, F., Wedemeyer, H., Sterneck, M., Berg, T., Sarrazin, C., Lutgehetmann, M., & Buggisch, P. (2012). Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: An international multicenter cohort study. Journal of Hepatology, 56(3), 520-526. https://doi.org/10.1016/j.jhep.2011.09.018