NUTRIZIONE ENTERALE DURANTE CHEMIO-RADIOTERAPIA NEL CARCINOMA ESOFAGEO

Translated title of the contribution: Enteral nutrition efficacy in patients with esophageal carcinoma receiving combined chemo-radiation therapy

L. Cozzaglio, F. Bozzetti, P. Bidoli, G. Bonfanti, L. Riva, A. Strisciuglio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In an attempt to increase the poor prognosis of patients with esophageal squamous cell carcinoma, many oncologists propose a combined chemotherapy and radiation therapy approach. In these patients drug-related dysphagia, anorexia and vomiting often lead to malnutrition. The aim of this study is to investigate the efficacy of enteral nutrition during a pre-operative combined chemoradiotherapy. We analyzed 37 malnourished patients divided into two groups: group I (CTR) patients without dysphagia and no nutritional support, group II (NE) patients with dysphagia supported by enteral feeding. Oncological therapies included 5-florouracil (1g/m2/day, dl-4) cisplatin (100mg/m2, dl) for two cycles associated with radiotherapy (30 Gy). We have evaluated the feasibility of enteral nutrition and its effects on the nutritional status and treatment tolerance. Tube feeding was delivered for a mean period of 33 days providing 37 Cal/kg/day and 2.1 g proteins/kg/day. Five patients stopped enteral nutrition before the end of oncological treatment because of an improvement of dysphagia. Nutritional evaluations demonstrated that during the chemoradiation therapy period, the CTR group had an impairment of body weight, total protein and albumin while there was no change in the NE group. No difference in the treatment tolerance between the two groups was found. Our study demonstrates that enteral nutrition is an easy way to prevent deterioration of nutritional status during chemoradiation therapy. Dysphagia is useful for indicating nutritional support.

Original languageItalian
Pages (from-to)37-42
Number of pages6
JournalRivista Italiana di Nutrizione Parenterale ed Enterale
Volume10
Issue number1
Publication statusPublished - 1992

Fingerprint

enteral feeding
Enteral Nutrition
radiotherapy
carcinoma
Deglutition Disorders
Radiotherapy
Carcinoma
Nutritional Support
nutritional support
Nutritional Status
therapeutics
nutritional status
Therapeutics
cisplatin
tube feeding
Self-Help Groups
squamous cell carcinoma
Anorexia
Chemoradiotherapy
vomiting

ASJC Scopus subject areas

  • Food Science
  • Anatomy
  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

Cozzaglio, L., Bozzetti, F., Bidoli, P., Bonfanti, G., Riva, L., & Strisciuglio, A. (1992). NUTRIZIONE ENTERALE DURANTE CHEMIO-RADIOTERAPIA NEL CARCINOMA ESOFAGEO. Rivista Italiana di Nutrizione Parenterale ed Enterale, 10(1), 37-42.

NUTRIZIONE ENTERALE DURANTE CHEMIO-RADIOTERAPIA NEL CARCINOMA ESOFAGEO. / Cozzaglio, L.; Bozzetti, F.; Bidoli, P.; Bonfanti, G.; Riva, L.; Strisciuglio, A.

In: Rivista Italiana di Nutrizione Parenterale ed Enterale, Vol. 10, No. 1, 1992, p. 37-42.

Research output: Contribution to journalArticle

Cozzaglio, L, Bozzetti, F, Bidoli, P, Bonfanti, G, Riva, L & Strisciuglio, A 1992, 'NUTRIZIONE ENTERALE DURANTE CHEMIO-RADIOTERAPIA NEL CARCINOMA ESOFAGEO', Rivista Italiana di Nutrizione Parenterale ed Enterale, vol. 10, no. 1, pp. 37-42.
Cozzaglio, L. ; Bozzetti, F. ; Bidoli, P. ; Bonfanti, G. ; Riva, L. ; Strisciuglio, A. / NUTRIZIONE ENTERALE DURANTE CHEMIO-RADIOTERAPIA NEL CARCINOMA ESOFAGEO. In: Rivista Italiana di Nutrizione Parenterale ed Enterale. 1992 ; Vol. 10, No. 1. pp. 37-42.
@article{523313d10273401d941278c072831e51,
title = "NUTRIZIONE ENTERALE DURANTE CHEMIO-RADIOTERAPIA NEL CARCINOMA ESOFAGEO",
abstract = "In an attempt to increase the poor prognosis of patients with esophageal squamous cell carcinoma, many oncologists propose a combined chemotherapy and radiation therapy approach. In these patients drug-related dysphagia, anorexia and vomiting often lead to malnutrition. The aim of this study is to investigate the efficacy of enteral nutrition during a pre-operative combined chemoradiotherapy. We analyzed 37 malnourished patients divided into two groups: group I (CTR) patients without dysphagia and no nutritional support, group II (NE) patients with dysphagia supported by enteral feeding. Oncological therapies included 5-florouracil (1g/m2/day, dl-4) cisplatin (100mg/m2, dl) for two cycles associated with radiotherapy (30 Gy). We have evaluated the feasibility of enteral nutrition and its effects on the nutritional status and treatment tolerance. Tube feeding was delivered for a mean period of 33 days providing 37 Cal/kg/day and 2.1 g proteins/kg/day. Five patients stopped enteral nutrition before the end of oncological treatment because of an improvement of dysphagia. Nutritional evaluations demonstrated that during the chemoradiation therapy period, the CTR group had an impairment of body weight, total protein and albumin while there was no change in the NE group. No difference in the treatment tolerance between the two groups was found. Our study demonstrates that enteral nutrition is an easy way to prevent deterioration of nutritional status during chemoradiation therapy. Dysphagia is useful for indicating nutritional support.",
author = "L. Cozzaglio and F. Bozzetti and P. Bidoli and G. Bonfanti and L. Riva and A. Strisciuglio",
year = "1992",
language = "Italian",
volume = "10",
pages = "37--42",
journal = "Rivista Italiana di Nutrizione Parenterale ed Enterale",
issn = "0393-5582",
publisher = "Wichtig Publishing",
number = "1",

}

TY - JOUR

T1 - NUTRIZIONE ENTERALE DURANTE CHEMIO-RADIOTERAPIA NEL CARCINOMA ESOFAGEO

AU - Cozzaglio, L.

AU - Bozzetti, F.

AU - Bidoli, P.

AU - Bonfanti, G.

AU - Riva, L.

AU - Strisciuglio, A.

PY - 1992

Y1 - 1992

N2 - In an attempt to increase the poor prognosis of patients with esophageal squamous cell carcinoma, many oncologists propose a combined chemotherapy and radiation therapy approach. In these patients drug-related dysphagia, anorexia and vomiting often lead to malnutrition. The aim of this study is to investigate the efficacy of enteral nutrition during a pre-operative combined chemoradiotherapy. We analyzed 37 malnourished patients divided into two groups: group I (CTR) patients without dysphagia and no nutritional support, group II (NE) patients with dysphagia supported by enteral feeding. Oncological therapies included 5-florouracil (1g/m2/day, dl-4) cisplatin (100mg/m2, dl) for two cycles associated with radiotherapy (30 Gy). We have evaluated the feasibility of enteral nutrition and its effects on the nutritional status and treatment tolerance. Tube feeding was delivered for a mean period of 33 days providing 37 Cal/kg/day and 2.1 g proteins/kg/day. Five patients stopped enteral nutrition before the end of oncological treatment because of an improvement of dysphagia. Nutritional evaluations demonstrated that during the chemoradiation therapy period, the CTR group had an impairment of body weight, total protein and albumin while there was no change in the NE group. No difference in the treatment tolerance between the two groups was found. Our study demonstrates that enteral nutrition is an easy way to prevent deterioration of nutritional status during chemoradiation therapy. Dysphagia is useful for indicating nutritional support.

AB - In an attempt to increase the poor prognosis of patients with esophageal squamous cell carcinoma, many oncologists propose a combined chemotherapy and radiation therapy approach. In these patients drug-related dysphagia, anorexia and vomiting often lead to malnutrition. The aim of this study is to investigate the efficacy of enteral nutrition during a pre-operative combined chemoradiotherapy. We analyzed 37 malnourished patients divided into two groups: group I (CTR) patients without dysphagia and no nutritional support, group II (NE) patients with dysphagia supported by enteral feeding. Oncological therapies included 5-florouracil (1g/m2/day, dl-4) cisplatin (100mg/m2, dl) for two cycles associated with radiotherapy (30 Gy). We have evaluated the feasibility of enteral nutrition and its effects on the nutritional status and treatment tolerance. Tube feeding was delivered for a mean period of 33 days providing 37 Cal/kg/day and 2.1 g proteins/kg/day. Five patients stopped enteral nutrition before the end of oncological treatment because of an improvement of dysphagia. Nutritional evaluations demonstrated that during the chemoradiation therapy period, the CTR group had an impairment of body weight, total protein and albumin while there was no change in the NE group. No difference in the treatment tolerance between the two groups was found. Our study demonstrates that enteral nutrition is an easy way to prevent deterioration of nutritional status during chemoradiation therapy. Dysphagia is useful for indicating nutritional support.

UR - http://www.scopus.com/inward/record.url?scp=0026639310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026639310&partnerID=8YFLogxK

M3 - Articolo

VL - 10

SP - 37

EP - 42

JO - Rivista Italiana di Nutrizione Parenterale ed Enterale

JF - Rivista Italiana di Nutrizione Parenterale ed Enterale

SN - 0393-5582

IS - 1

ER -