Entering neurons: Botulinum toxins and synaptic vesicle recycling

Claudia Verderio, Ornella Rossetto, Carlotta Grumelli, Carolina Frassoni, Cesare Montecucco, Michela Matteoli

Research output: Contribution to journalArticlepeer-review

Abstract

Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release through their cleavage of components of the exocytosis machinery. These toxins are used to treat human diseases that are characterized by hyperfunction of cholinergic terminals. Recently, evidence has accumulated that gangliosides and synaptic vesicle proteins cooperate to mediate toxin binding to the presynaptic terminal. The differential distribution of synaptic vesicle protein receptors, gangliosides and toxin substrates in distinct neuronal populations opens up the possibility of using different serotypes of botulinum toxins for the treatment of central nervous system diseases caused by altered activity of selected neuronal populations.

Original languageEnglish
Pages (from-to)995-999
Number of pages5
JournalEMBO Reports
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 2006

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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