Enterohepatic recycling of N-nitrosodiethanolamine in rats

M. Bonfanti, M. G. Castelli, R. Fanelli, L. Airoldi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

N-Nitrosodiethanolamine (NDELA) was administered to rats whose bile was drained directly into the duodenum of a second group of animals, in which the natural bile flow was ligated, thus simulating enterohepatic circulation. The presence of NDELA and its metabolite N-(2-hydroxyethyl)-N-(carboxymethyl)nitrosamine in the urine of the 'bile-recipient' rats indicated that NDELA was first excreted into the bile and then reabsorbed from the duodenum into the bloodstream. The enterohepatic recycling of NDELA may be a factor in the compound's known hepatocarcinogenicity.

Original languageEnglish
Pages (from-to)1011-1013
Number of pages3
JournalFood and Chemical Toxicology
Volume23
Issue number11
DOIs
Publication statusPublished - 1985

Fingerprint

bile
Bile
recycling
Recycling
Rats
rats
duodenum
Duodenum
Enterohepatic Circulation
nitrosamines
Nitrosamines
Metabolites
blood flow
Animals
urine
Urine
metabolites
N-nitrosodiethanolamine
animals

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Enterohepatic recycling of N-nitrosodiethanolamine in rats. / Bonfanti, M.; Castelli, M. G.; Fanelli, R.; Airoldi, L.

In: Food and Chemical Toxicology, Vol. 23, No. 11, 1985, p. 1011-1013.

Research output: Contribution to journalArticle

Bonfanti, M. ; Castelli, M. G. ; Fanelli, R. ; Airoldi, L. / Enterohepatic recycling of N-nitrosodiethanolamine in rats. In: Food and Chemical Toxicology. 1985 ; Vol. 23, No. 11. pp. 1011-1013.
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