Enterovirus D-68: An emerging cause of infection

Nicola Principi, Susanna Esposito

Research output: Contribution to journalArticlepeer-review


The outbreak of Enterovirus D-68 (EV-D68) in the United States in 2014 raised great interest due to it affecting large numbers of people and because patients presented with severe respiratory and/or central nervous system involvement. Many studies have tried to evaluate the biologic and genetic characteristics of this virus, its association with disease development and the possibility of infection prevention and therapy. The main aim of this paper is to discuss what is presently known and what might be expected in the future regarding EV-D68. We highlight that further studies are needed to precisely define the epidemiology and total burden of EV-D68, the real age prevalence, and the factors that may lead to negative outcomes in some patients and not in others. Moreover, if recently reported clinical data are confirmed, specific efficacious prophylactic and therapeutic measures should be urgently developed.

Original languageEnglish
Pages (from-to)711-719
Number of pages9
JournalExpert Review of Respiratory Medicine
Issue number6
Publication statusPublished - Nov 2 2015


  • Emerging viruses
  • Enterovirus D-68
  • EV-D68
  • Meningitis
  • Poliovirus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health


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