Abstract
Long-term potentiation (LTP) induced in the lateral entorhinal cortex by theta-patterned tetanic stimulation of the piriform cortex was analyzed in the isolated guinea pig brain maintained in vitro. Monosynaptic excitatory postsynaptic potentials (EPSPs) evoked by stimulation of the piriform cortex are composed of an early and late component selectively blocked by non-N-methyl-d-aspartate (non-NMDA) and NMDA receptor antagonists, respectively. LTP induction was dependent on NMDA receptor activation, being blocked by perfusing the preparation with 2-amino-5-phosphonovalerate (AP-5). LTP was expressed through synaptic enhancement of both early non-NMDA and late, possibly NMDA receptor-mediated responses.
Original language | English |
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Pages (from-to) | 327-330 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 600 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jan 15 1993 |
Keywords
- Entorhinal cortex
- Isolated brain in vitro
- Long-term potentiation
- NMDA receptor
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)