Abstract
Brake-assisted drive. Saccharide recognition by lectins involves several critical hydrogen-bonding interactions. This manifests as favorable enthalpic contributions that are strongly opposed by entropic factors. In contrast, sialooligo-saccharide recognition by Sigle-7 utilizes favorable hydrogen-bonding and hydrophobic interactions. The binding free-energy change is assisted by favorable contributions from enthalpic and entropic components (see figure), and entropic factors no longer appear to serve as "brakes".
Original language | English |
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Pages (from-to) | 1571-1575 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 5 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 5 2004 |
Keywords
- Calorimetry
- Carbohydrates
- Molecular recognition
- Receptors
- Sialic acids
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Biochemistry, Genetics and Molecular Biology(all)