Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor

Chittoor P. Swaminathan, Neelowfar Wais, Vinay V. Vyas, Carlos A. Velikovsky, Alessandro Moretta, Lorenzo Moretta, Roberto Biassoni, Roy A. Mariuzza, Nazzareno Dimasi

Research output: Contribution to journalArticle

Abstract

Brake-assisted drive. Saccharide recognition by lectins involves several critical hydrogen-bonding interactions. This manifests as favorable enthalpic contributions that are strongly opposed by entropic factors. In contrast, sialooligo-saccharide recognition by Sigle-7 utilizes favorable hydrogen-bonding and hydrophobic interactions. The binding free-energy change is assisted by favorable contributions from enthalpic and entropic components (see figure), and entropic factors no longer appear to serve as "brakes".

Original languageEnglish
Pages (from-to)1571-1575
Number of pages5
JournalChemBioChem
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 5 2004

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Keywords

  • Calorimetry
  • Carbohydrates
  • Molecular recognition
  • Receptors
  • Sialic acids

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Swaminathan, C. P., Wais, N., Vyas, V. V., Velikovsky, C. A., Moretta, A., Moretta, L., Biassoni, R., Mariuzza, R. A., & Dimasi, N. (2004). Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor. ChemBioChem, 5(11), 1571-1575. https://doi.org/10.1002/cbic.200400130