Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor

Chittoor P. Swaminathan; Neelowfar Wais; Vinay V. Vyas; Carlos A. Velikovsky; Alessandro Moretta; Lorenzo Moretta; Roberto Biassoni; Roy A. Mariuzza; Nazzareno Dimasi

doi:10.1002/cbic.200400130

Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor

Chittoor P. Swaminathan, Neelowfar Wais, Vinay V. Vyas, Carlos A. Velikovsky, Alessandro Moretta, Lorenzo Moretta, Roberto Biassoni, Roy A. Mariuzza, Nazzareno Dimasi

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article

Abstract

Brake-assisted drive. Saccharide recognition by lectins involves several critical hydrogen-bonding interactions. This manifests as favorable enthalpic contributions that are strongly opposed by entropic factors. In contrast, sialooligo-saccharide recognition by Sigle-7 utilizes favorable hydrogen-bonding and hydrophobic interactions. The binding free-energy change is assisted by favorable contributions from enthalpic and entropic components (see figure), and entropic factors no longer appear to serve as "brakes".

Original language	English
Pages (from-to)	1571-1575
Number of pages	5
Journal	ChemBioChem
Volume	5
Issue number	11
DOIs	https://doi.org/10.1002/cbic.200400130
Publication status	Published - Nov 5 2004

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Keywords

Calorimetry
Carbohydrates
Molecular recognition
Receptors
Sialic acids

ASJC Scopus subject areas

Drug Discovery
Organic Chemistry
Biochemistry, Genetics and Molecular Biology(all)

Cite this

Swaminathan, C. P., Wais, N., Vyas, V. V., Velikovsky, C. A., Moretta, A., Moretta, L., Biassoni, R., Mariuzza, R. A., & Dimasi, N. (2004). Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor. ChemBioChem, 5(11), 1571-1575. https://doi.org/10.1002/cbic.200400130

Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor. / Swaminathan, Chittoor P.; Wais, Neelowfar; Vyas, Vinay V.; Velikovsky, Carlos A.; Moretta, Alessandro; Moretta, Lorenzo ; Biassoni, Roberto; Mariuzza, Roy A.; Dimasi, Nazzareno.

In: ChemBioChem, Vol. 5, No. 11, 05.11.2004, p. 1571-1575.

Research output: Contribution to journal › Article

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Access to Document

10.1002/cbic.200400130