Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor

Chittoor P. Swaminathan; Neelowfar Wais; Vinay V. Vyas; Carlos A. Velikovsky; Alessandro Moretta; Lorenzo Moretta; Roberto Biassoni; Roy A. Mariuzza; Nazzareno Dimasi

doi:10.1002/cbic.200400130

Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor

Chittoor P. Swaminathan, Neelowfar Wais, Vinay V. Vyas, Carlos A. Velikovsky, Alessandro Moretta, Lorenzo Moretta, Roberto Biassoni, Roy A. Mariuzza, Nazzareno Dimasi

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Brake-assisted drive. Saccharide recognition by lectins involves several critical hydrogen-bonding interactions. This manifests as favorable enthalpic contributions that are strongly opposed by entropic factors. In contrast, sialooligo-saccharide recognition by Sigle-7 utilizes favorable hydrogen-bonding and hydrophobic interactions. The binding free-energy change is assisted by favorable contributions from enthalpic and entropic components (see figure), and entropic factors no longer appear to serve as "brakes".

Original language	English
Pages (from-to)	1571-1575
Number of pages	5
Journal	ChemBioChem
Volume	5
Issue number	11
DOIs	https://doi.org/10.1002/cbic.200400130
Publication status	Published - Nov 5 2004

Keywords

Calorimetry
Carbohydrates
Molecular recognition
Receptors
Sialic acids

ASJC Scopus subject areas

Drug Discovery
Organic Chemistry
Biochemistry, Genetics and Molecular Biology(all)

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10.1002/cbic.200400130

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Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor. / Swaminathan, Chittoor P.; Wais, Neelowfar; Vyas, Vinay V.; Velikovsky, Carlos A.; Moretta, Alessandro; Moretta, Lorenzo ; Biassoni, Roberto; Mariuzza, Roy A.; Dimasi, Nazzareno.

In: ChemBioChem, Vol. 5, No. 11, 05.11.2004, p. 1571-1575.

Research output: Contribution to journal › Article › peer-review

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AU - Swaminathan, Chittoor P.

AU - Wais, Neelowfar

AU - Vyas, Vinay V.

AU - Velikovsky, Carlos A.

AU - Moretta, Alessandro

AU - Moretta, Lorenzo

AU - Biassoni, Roberto

AU - Mariuzza, Roy A.

AU - Dimasi, Nazzareno

PY - 2004/11/5

Y1 - 2004/11/5

N2 - Brake-assisted drive. Saccharide recognition by lectins involves several critical hydrogen-bonding interactions. This manifests as favorable enthalpic contributions that are strongly opposed by entropic factors. In contrast, sialooligo-saccharide recognition by Sigle-7 utilizes favorable hydrogen-bonding and hydrophobic interactions. The binding free-energy change is assisted by favorable contributions from enthalpic and entropic components (see figure), and entropic factors no longer appear to serve as "brakes".

AB - Brake-assisted drive. Saccharide recognition by lectins involves several critical hydrogen-bonding interactions. This manifests as favorable enthalpic contributions that are strongly opposed by entropic factors. In contrast, sialooligo-saccharide recognition by Sigle-7 utilizes favorable hydrogen-bonding and hydrophobic interactions. The binding free-energy change is assisted by favorable contributions from enthalpic and entropic components (see figure), and entropic factors no longer appear to serve as "brakes".

KW - Calorimetry

KW - Carbohydrates

KW - Molecular recognition

KW - Receptors

KW - Sialic acids

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Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor

Abstract

Keywords

ASJC Scopus subject areas

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