Entropy modulation of electroencephalographic signals in physiological aging

Francesca Alù, Alessandro Orticoni, Elda Judica, Maria Cotelli, Paolo Maria Rossini, Francesca Miraglia, Fabrizio Vecchio

Research output: Contribution to journalArticlepeer-review

Abstract

Aging is a multifactorial physiological process characterized by the accumulation of degenerative processes impacting on different brain functions, including the cognitive one. A tool largely employed in the investigation of brain networks is the electroencephalogram (EEG). Given the cerebral complexity and dynamism, many non-linear approaches have been applied to explore age-related brain electrical activity modulation detected by the EEG: one of them is the entropy, which measures the disorder of a system. The present study had the aim to investigate aging influence on brain dynamics applying Approximate Entropy (ApEn) parameter to resting state EEG data of 68 healthy adult participants, divided with respect to their age in two groups, focusing on several specialized brain regions. Results showed that elderly participants present higher ApEn values than younger participants in the central, parietal and occipital areas, confirming the hypothesis that aging is characterized by an evolution of brain dynamics. Such findings may reflect a reduced synchronization of the neural networks cyclic activity, due to the reduction of cerebral connections typically found in aging process. Understanding the dynamics of brain networks by applying the entropy parameter could be useful for developing appropriate and personalized rehabilitation programs and for future studies on neurodegenerative diseases.

Original languageEnglish
Article number111472
JournalMechanisms of Ageing and Development
Volume196
DOIs
Publication statusPublished - Jun 2021

Keywords

  • Age
  • Brain network
  • EEG
  • Nonlinearity

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

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