Entry Route of Salmonella typhimurium Directs the Type of Induced Immune Response

Chiara Martinoli, Andrea Chiavelli, Maria Rescigno

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Secretory immunoglobulin A (SIgA) represents a first line of defense against mucosal pathogens by limiting their entrance. By using different strains of Salmonella typhimurium that target the two mechanisms of bacterial entry (microfold cell [M cell]- or dendritic cell-mediated), we demonstrated here that the distribution of bacteria after oral infection directed the type of induced immune response. M cell-penetrating invasive, but not noninvasive, S. typhimurium was found in large numbers in Peyer's patches (PPs), leading to the activation of immune cells and the release of fecal IgA. In contrast, both strains of bacteria were equally capable of reaching the mesenteric lymph node and the spleen and inducing IgG responses. These data suggest that PPs are absolutely required for the initiation of an IgA response to Salmonella, whereas they are dispensable for a systemic response. This compartmentalization could allow the fast generation of both mucosal and systemic acquired immunity to pathogens.

Original languageEnglish
Pages (from-to)975-984
Number of pages10
JournalImmunity
Volume27
Issue number6
DOIs
Publication statusPublished - Dec 21 2007

Fingerprint

Salmonella typhimurium
Peyer's Patches
Immunoglobulin A
Bacteria
Secretory Immunoglobulin A
Adaptive Immunity
Salmonella
Dendritic Cells
Spleen
Immunoglobulin G
Lymph Nodes
Infection

Keywords

  • CELLIMMUNO

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Entry Route of Salmonella typhimurium Directs the Type of Induced Immune Response. / Martinoli, Chiara; Chiavelli, Andrea; Rescigno, Maria.

In: Immunity, Vol. 27, No. 6, 21.12.2007, p. 975-984.

Research output: Contribution to journalArticle

Martinoli, Chiara ; Chiavelli, Andrea ; Rescigno, Maria. / Entry Route of Salmonella typhimurium Directs the Type of Induced Immune Response. In: Immunity. 2007 ; Vol. 27, No. 6. pp. 975-984.
@article{3b714835f4ab4d54b5cf5f381e93103a,
title = "Entry Route of Salmonella typhimurium Directs the Type of Induced Immune Response",
abstract = "Secretory immunoglobulin A (SIgA) represents a first line of defense against mucosal pathogens by limiting their entrance. By using different strains of Salmonella typhimurium that target the two mechanisms of bacterial entry (microfold cell [M cell]- or dendritic cell-mediated), we demonstrated here that the distribution of bacteria after oral infection directed the type of induced immune response. M cell-penetrating invasive, but not noninvasive, S. typhimurium was found in large numbers in Peyer's patches (PPs), leading to the activation of immune cells and the release of fecal IgA. In contrast, both strains of bacteria were equally capable of reaching the mesenteric lymph node and the spleen and inducing IgG responses. These data suggest that PPs are absolutely required for the initiation of an IgA response to Salmonella, whereas they are dispensable for a systemic response. This compartmentalization could allow the fast generation of both mucosal and systemic acquired immunity to pathogens.",
keywords = "CELLIMMUNO",
author = "Chiara Martinoli and Andrea Chiavelli and Maria Rescigno",
year = "2007",
month = "12",
day = "21",
doi = "10.1016/j.immuni.2007.10.011",
language = "English",
volume = "27",
pages = "975--984",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Entry Route of Salmonella typhimurium Directs the Type of Induced Immune Response

AU - Martinoli, Chiara

AU - Chiavelli, Andrea

AU - Rescigno, Maria

PY - 2007/12/21

Y1 - 2007/12/21

N2 - Secretory immunoglobulin A (SIgA) represents a first line of defense against mucosal pathogens by limiting their entrance. By using different strains of Salmonella typhimurium that target the two mechanisms of bacterial entry (microfold cell [M cell]- or dendritic cell-mediated), we demonstrated here that the distribution of bacteria after oral infection directed the type of induced immune response. M cell-penetrating invasive, but not noninvasive, S. typhimurium was found in large numbers in Peyer's patches (PPs), leading to the activation of immune cells and the release of fecal IgA. In contrast, both strains of bacteria were equally capable of reaching the mesenteric lymph node and the spleen and inducing IgG responses. These data suggest that PPs are absolutely required for the initiation of an IgA response to Salmonella, whereas they are dispensable for a systemic response. This compartmentalization could allow the fast generation of both mucosal and systemic acquired immunity to pathogens.

AB - Secretory immunoglobulin A (SIgA) represents a first line of defense against mucosal pathogens by limiting their entrance. By using different strains of Salmonella typhimurium that target the two mechanisms of bacterial entry (microfold cell [M cell]- or dendritic cell-mediated), we demonstrated here that the distribution of bacteria after oral infection directed the type of induced immune response. M cell-penetrating invasive, but not noninvasive, S. typhimurium was found in large numbers in Peyer's patches (PPs), leading to the activation of immune cells and the release of fecal IgA. In contrast, both strains of bacteria were equally capable of reaching the mesenteric lymph node and the spleen and inducing IgG responses. These data suggest that PPs are absolutely required for the initiation of an IgA response to Salmonella, whereas they are dispensable for a systemic response. This compartmentalization could allow the fast generation of both mucosal and systemic acquired immunity to pathogens.

KW - CELLIMMUNO

UR - http://www.scopus.com/inward/record.url?scp=37049033289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37049033289&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2007.10.011

DO - 10.1016/j.immuni.2007.10.011

M3 - Article

C2 - 18083577

AN - SCOPUS:37049033289

VL - 27

SP - 975

EP - 984

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 6

ER -