Environment makes amphetamine-induced dopamine release in the nucleus accumbens totally impulse-dependent

Rossella Ventura, Stefano Puglisi-Allegra

Research output: Contribution to journal › Article

Abstract

Environmental condition such as food restriction has been shown to produce sensitization to the stimulant and rewarding effects of amphetamine in the low responsive DBA/2J genotype. Here, we report that food-restricted DBA/2J mice lose the impulse-independent component of psychostimulant-induced dopamine release in the nucleus accumbens that is replaced totally by impulse-dependent dopamine release. These results indicate for the first time that the crucial effect of environment-induced sensitization is a dramatic increase of the impulse dependent component.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalSynapse
Volume58
Issue number3
DOIs
Publication statusPublished - Dec 1 2005

Keywords

  • Drug abuse
  • Psychostimulants
  • Schizophrenia
  • Sensitization

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pharmacology
  • Advanced and Specialised Nursing

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