Abstract
Environmental condition such as food restriction has been shown to produce sensitization to the stimulant and rewarding effects of amphetamine in the low responsive DBA/2J genotype. Here, we report that food-restricted DBA/2J mice lose the impulse-independent component of psychostimulant-induced dopamine release in the nucleus accumbens that is replaced totally by impulse-dependent dopamine release. These results indicate for the first time that the crucial effect of environment-induced sensitization is a dramatic increase of the impulse dependent component.
| Original language | English |
|---|---|
| Pages (from-to) | 211-214 |
| Number of pages | 4 |
| Journal | Synapse |
| Volume | 58 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 1 2005 |
Keywords
- Drug abuse
- Psychostimulants
- Schizophrenia
- Sensitization
ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
- Pharmacology
- Advanced and Specialised Nursing