Abstract
Environmental condition such as food restriction has been shown to produce sensitization to the stimulant and rewarding effects of amphetamine in the low responsive DBA/2J genotype. Here, we report that food-restricted DBA/2J mice lose the impulse-independent component of psychostimulant-induced dopamine release in the nucleus accumbens that is replaced totally by impulse-dependent dopamine release. These results indicate for the first time that the crucial effect of environment-induced sensitization is a dramatic increase of the impulse dependent component.
Original language | English |
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Pages (from-to) | 211-214 |
Number of pages | 4 |
Journal | Synapse |
Volume | 58 |
Issue number | 3 |
DOIs | |
Publication status | Published - Dec 1 2005 |
Keywords
- Drug abuse
- Psychostimulants
- Schizophrenia
- Sensitization
ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
- Pharmacology
- Advanced and Specialised Nursing