Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood

A European mother–child study (NewGeneris)

Marie Pedersen, Michelle A. Mendez, Bernadette Schoket, Roger W. Godschalk, Ana Espinosa, Anette Landström, Cristina M. Villanueva, Domenico F. Merlo, Eleni Fthenou, Esther Gracia-Lavedan, Frederik J. van Schooten, Gerard Hoek, Gunnar Brunborg, Helle M. Meltzer, Jan Alexander, Jeanette K. Nielsen, Jordi Sunyer, John Wright, Katalin Kovács, Kees de Hoogh & 19 others Kristine B. Gutzkow, Laura J. Hardie, Leda Chatzi, Lisbeth E. Knudsen, Lívia Anna, Matthias Ketzel, Margaretha Haugen, Maria Botsivali, Mark J. Nieuwenhuijsen, Marta Cirach, Mireille B. Toledano, Rachel B. Smith, Sarah Fleming, Silvia Agramunt, Soterios A. Kyrtopoulos, Viktória Lukács, Jos C. Kleinjans, Dan Segerbäck, Manolis Kogevinas

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. oBjective: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. Methods: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006–2010. Cord blood bulky DNA adduct levels were measured by the32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population. results: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p <0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England. conclusion: These findings suggest that a combination of factors, including unknown countryspecific factors, influence the bulky DNA adduct levels in neonates.

Original languageEnglish
Pages (from-to)374-380
Number of pages7
JournalEnvironmental Health Perspectives
Volume123
Issue number4
DOIs
Publication statusPublished - 2015

Fingerprint

DNA Adducts
Fetal Blood
Trihalomethanes
Mothers
Newborn Infant
England
Nitrogen Dioxide
Air Pollutants
Dairy Products
Particulate Matter
Greece
Disinfection
Denmark
Norway
Birth Weight
Cesarean Section
Drinking Water
Spain
Ascorbic Acid
Pregnant Women

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Pedersen, M., Mendez, M. A., Schoket, B., Godschalk, R. W., Espinosa, A., Landström, A., ... Kogevinas, M. (2015). Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: A European mother–child study (NewGeneris). Environmental Health Perspectives, 123(4), 374-380. https://doi.org/10.1289/ehp.1408613

Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood : A European mother–child study (NewGeneris). / Pedersen, Marie; Mendez, Michelle A.; Schoket, Bernadette; Godschalk, Roger W.; Espinosa, Ana; Landström, Anette; Villanueva, Cristina M.; Merlo, Domenico F.; Fthenou, Eleni; Gracia-Lavedan, Esther; van Schooten, Frederik J.; Hoek, Gerard; Brunborg, Gunnar; Meltzer, Helle M.; Alexander, Jan; Nielsen, Jeanette K.; Sunyer, Jordi; Wright, John; Kovács, Katalin; de Hoogh, Kees; Gutzkow, Kristine B.; Hardie, Laura J.; Chatzi, Leda; Knudsen, Lisbeth E.; Anna, Lívia; Ketzel, Matthias; Haugen, Margaretha; Botsivali, Maria; Nieuwenhuijsen, Mark J.; Cirach, Marta; Toledano, Mireille B.; Smith, Rachel B.; Fleming, Sarah; Agramunt, Silvia; Kyrtopoulos, Soterios A.; Lukács, Viktória; Kleinjans, Jos C.; Segerbäck, Dan; Kogevinas, Manolis.

In: Environmental Health Perspectives, Vol. 123, No. 4, 2015, p. 374-380.

Research output: Contribution to journalArticle

Pedersen, M, Mendez, MA, Schoket, B, Godschalk, RW, Espinosa, A, Landström, A, Villanueva, CM, Merlo, DF, Fthenou, E, Gracia-Lavedan, E, van Schooten, FJ, Hoek, G, Brunborg, G, Meltzer, HM, Alexander, J, Nielsen, JK, Sunyer, J, Wright, J, Kovács, K, de Hoogh, K, Gutzkow, KB, Hardie, LJ, Chatzi, L, Knudsen, LE, Anna, L, Ketzel, M, Haugen, M, Botsivali, M, Nieuwenhuijsen, MJ, Cirach, M, Toledano, MB, Smith, RB, Fleming, S, Agramunt, S, Kyrtopoulos, SA, Lukács, V, Kleinjans, JC, Segerbäck, D & Kogevinas, M 2015, 'Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: A European mother–child study (NewGeneris)', Environmental Health Perspectives, vol. 123, no. 4, pp. 374-380. https://doi.org/10.1289/ehp.1408613
Pedersen, Marie ; Mendez, Michelle A. ; Schoket, Bernadette ; Godschalk, Roger W. ; Espinosa, Ana ; Landström, Anette ; Villanueva, Cristina M. ; Merlo, Domenico F. ; Fthenou, Eleni ; Gracia-Lavedan, Esther ; van Schooten, Frederik J. ; Hoek, Gerard ; Brunborg, Gunnar ; Meltzer, Helle M. ; Alexander, Jan ; Nielsen, Jeanette K. ; Sunyer, Jordi ; Wright, John ; Kovács, Katalin ; de Hoogh, Kees ; Gutzkow, Kristine B. ; Hardie, Laura J. ; Chatzi, Leda ; Knudsen, Lisbeth E. ; Anna, Lívia ; Ketzel, Matthias ; Haugen, Margaretha ; Botsivali, Maria ; Nieuwenhuijsen, Mark J. ; Cirach, Marta ; Toledano, Mireille B. ; Smith, Rachel B. ; Fleming, Sarah ; Agramunt, Silvia ; Kyrtopoulos, Soterios A. ; Lukács, Viktória ; Kleinjans, Jos C. ; Segerbäck, Dan ; Kogevinas, Manolis. / Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood : A European mother–child study (NewGeneris). In: Environmental Health Perspectives. 2015 ; Vol. 123, No. 4. pp. 374-380.
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abstract = "Background: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. oBjective: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. Methods: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006–2010. Cord blood bulky DNA adduct levels were measured by the32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population. results: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p <0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England. conclusion: These findings suggest that a combination of factors, including unknown countryspecific factors, influence the bulky DNA adduct levels in neonates.",
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T1 - Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood

T2 - A European mother–child study (NewGeneris)

AU - Pedersen, Marie

AU - Mendez, Michelle A.

AU - Schoket, Bernadette

AU - Godschalk, Roger W.

AU - Espinosa, Ana

AU - Landström, Anette

AU - Villanueva, Cristina M.

AU - Merlo, Domenico F.

AU - Fthenou, Eleni

AU - Gracia-Lavedan, Esther

AU - van Schooten, Frederik J.

AU - Hoek, Gerard

AU - Brunborg, Gunnar

AU - Meltzer, Helle M.

AU - Alexander, Jan

AU - Nielsen, Jeanette K.

AU - Sunyer, Jordi

AU - Wright, John

AU - Kovács, Katalin

AU - de Hoogh, Kees

AU - Gutzkow, Kristine B.

AU - Hardie, Laura J.

AU - Chatzi, Leda

AU - Knudsen, Lisbeth E.

AU - Anna, Lívia

AU - Ketzel, Matthias

AU - Haugen, Margaretha

AU - Botsivali, Maria

AU - Nieuwenhuijsen, Mark J.

AU - Cirach, Marta

AU - Toledano, Mireille B.

AU - Smith, Rachel B.

AU - Fleming, Sarah

AU - Agramunt, Silvia

AU - Kyrtopoulos, Soterios A.

AU - Lukács, Viktória

AU - Kleinjans, Jos C.

AU - Segerbäck, Dan

AU - Kogevinas, Manolis

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