Environmental enrichment decreases gabaergic inhibition and improves cognitive abilities, synaptic plasticity and visual functions in a mouse model of down syndrome

Tatjana Begenisic, Maria Spolidoro, Chiara Braschi, Laura Baroncelli, Marco Milanese, Gianluca Pietra, Maria Elena Fabbri, Giambattista Bonanno, Giovanni Cioni, Lamberto Maffei, Alessandro Sale

Research output: Contribution to journalArticlepeer-review

Abstract

Down syndrome (DS) is the most common genetic disorder associated with mental retardation. It has been repeatedly shown that Ts65Dn mice, the prime animal model for DS, have severe cognitive and neural plasticity defects due to excessive inhibition. We report that increasing sensory-motor stimulation in adulthood through environmental enrichment reduces brain inhibition levels and promotes recovery of spatial memory abilities, hippocampal synaptic plasticity and visual functions in adult Ts65Dn mice.

Original languageEnglish
Pages (from-to)1-22
Number of pages22
JournalFrontiers in Cellular Neuroscience
Issue numberDECEMBER
DOIs
Publication statusPublished - Dec 12 2011

Keywords

  • Cerebral plasticity
  • Down syndrome
  • Environmental enrichment
  • GABAergic inhibition
  • Ts65Dn mice

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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