Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice

Emanuela Morelli; Veronica Ghiglieri; Valentina Pendolino; Vincenza Bagetta; Annabella Pignataro; Anna Fejtova; Cinzia Costa; Martine Ammassari-Teule; Eckart D. Gundelfinger; Barbara Picconi; Paolo Calabresi

doi:10.1016/j.expneurol.2014.05.010

Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice

Emanuela Morelli, Veronica Ghiglieri, Valentina Pendolino, Vincenza Bagetta, Annabella Pignataro, Anna Fejtova, Cinzia Costa, Martine Ammassari-Teule, Eckart D. Gundelfinger, Barbara Picconi, Paolo Calabresi

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented the reduction of spine density and dendrite branching of pyramidal neurons. These data demonstrate that EE exerts its therapeutic effect by normalizing multiple aspects of hippocampal function and provide experimental support for its use in the optimization of existent treatments.

Original language	English
Pages (from-to)	320-327
Number of pages	8
Journal	Experimental Neurology
Volume	261
DOIs	https://doi.org/10.1016/j.expneurol.2014.05.010
Publication status	Published - 2014

Keywords

Bassoon
Environmental enrichment
Epilepsy
Hippocampus
Neurodevelopmental disorder
Synaptic plasticity

ASJC Scopus subject areas

Neurology
Developmental Neuroscience
Medicine(all)

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Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice. / Morelli, Emanuela; Ghiglieri, Veronica; Pendolino, Valentina; Bagetta, Vincenza; Pignataro, Annabella; Fejtova, Anna; Costa, Cinzia; Ammassari-Teule, Martine; Gundelfinger, Eckart D.; Picconi, Barbara ; Calabresi, Paolo.

In: Experimental Neurology, Vol. 261, 2014, p. 320-327.

Research output: Contribution to journal › Article › peer-review

Morelli, Emanuela ; Ghiglieri, Veronica ; Pendolino, Valentina ; Bagetta, Vincenza ; Pignataro, Annabella ; Fejtova, Anna ; Costa, Cinzia ; Ammassari-Teule, Martine ; Gundelfinger, Eckart D. ; Picconi, Barbara ; Calabresi, Paolo. / Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice. In: Experimental Neurology. 2014 ; Vol. 261. pp. 320-327.

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abstract = "We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented the reduction of spine density and dendrite branching of pyramidal neurons. These data demonstrate that EE exerts its therapeutic effect by normalizing multiple aspects of hippocampal function and provide experimental support for its use in the optimization of existent treatments.",

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AU - Bagetta, Vincenza

AU - Pignataro, Annabella

AU - Fejtova, Anna

AU - Costa, Cinzia

AU - Ammassari-Teule, Martine

AU - Gundelfinger, Eckart D.

AU - Picconi, Barbara

AU - Calabresi, Paolo

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KW - Synaptic plasticity

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Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice

Abstract

Keywords

ASJC Scopus subject areas

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