Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice

Emanuela Morelli, Veronica Ghiglieri, Valentina Pendolino, Vincenza Bagetta, Annabella Pignataro, Anna Fejtova, Cinzia Costa, Martine Ammassari-Teule, Eckart D. Gundelfinger, Barbara Picconi, Paolo Calabresi

Research output: Contribution to journalArticle

Abstract

We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented the reduction of spine density and dendrite branching of pyramidal neurons. These data demonstrate that EE exerts its therapeutic effect by normalizing multiple aspects of hippocampal function and provide experimental support for its use in the optimization of existent treatments.

Original languageEnglish
Pages (from-to)320-327
Number of pages8
JournalExperimental Neurology
Volume261
DOIs
Publication statusPublished - 2014

Keywords

  • Bassoon
  • Environmental enrichment
  • Epilepsy
  • Hippocampus
  • Neurodevelopmental disorder
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Medicine(all)

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  • Cite this

    Morelli, E., Ghiglieri, V., Pendolino, V., Bagetta, V., Pignataro, A., Fejtova, A., Costa, C., Ammassari-Teule, M., Gundelfinger, E. D., Picconi, B., & Calabresi, P. (2014). Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice. Experimental Neurology, 261, 320-327. https://doi.org/10.1016/j.expneurol.2014.05.010