TY - JOUR
T1 - Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice
AU - Morelli, Emanuela
AU - Ghiglieri, Veronica
AU - Pendolino, Valentina
AU - Bagetta, Vincenza
AU - Pignataro, Annabella
AU - Fejtova, Anna
AU - Costa, Cinzia
AU - Ammassari-Teule, Martine
AU - Gundelfinger, Eckart D.
AU - Picconi, Barbara
AU - Calabresi, Paolo
PY - 2014
Y1 - 2014
N2 - We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented the reduction of spine density and dendrite branching of pyramidal neurons. These data demonstrate that EE exerts its therapeutic effect by normalizing multiple aspects of hippocampal function and provide experimental support for its use in the optimization of existent treatments.
AB - We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented the reduction of spine density and dendrite branching of pyramidal neurons. These data demonstrate that EE exerts its therapeutic effect by normalizing multiple aspects of hippocampal function and provide experimental support for its use in the optimization of existent treatments.
KW - Bassoon
KW - Environmental enrichment
KW - Epilepsy
KW - Hippocampus
KW - Neurodevelopmental disorder
KW - Synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=84905450913&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905450913&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2014.05.010
DO - 10.1016/j.expneurol.2014.05.010
M3 - Article
C2 - 24858730
AN - SCOPUS:84905450913
VL - 261
SP - 320
EP - 327
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
ER -