Environmental epigenetics

V. Bollati, A. Baccarelli

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

Epigenetics investigates heritable changes in gene expression that occur without changes in DNA sequence. Several epigenetic mechanisms, including DNA methylation and histone modifications, can change genome function under exogenous influence. We review current evidence indicating that epigenetic alterations mediate effects caused by exposure to environmental toxicants. Results obtained from animal models indicate that in utero or early-life environmental exposures produce effects that can be inherited transgenerationally and are accompanied by epigenetic alterations. The search for human equivalents of the epigenetic mechanisms identified in animal models is under way. Recent investigations have identified a number of environmental toxicants that cause altered methylation of human repetitive elements or genes. Some exposures can alter epigenetic states and the same and/or similar epigenetic alterations can be found in patients with the disease of concern. On the basis of current evidence, we propose possible models for the interplay between environmental exposures and the human epigenome. Several investigations have examined the relationship between exposure to environmental chemicals and epigenetics, and have identified toxicants that modify epigenetic states. Whether environmental exposures have transgenerational epigenetic effects in humans remains to be elucidated. In spite of the current limitations, available evidence supports the concept that epigenetics holds substantial potential for furthering our understanding of the molecular mechanisms of environmental toxicants, as well as for predicting health-related risks due to conditions of environmental exposure and individual susceptibility.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalHeredity
Volume105
Issue number1
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Epigenomics
Environmental Exposure
Histone Code
Animal Models
DNA Methylation
Methylation
Genome
Gene Expression
Health

Keywords

  • DNA methylation
  • Environmental exposures
  • Epigenetics
  • Histone modifications
  • Transgenerational effects

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Medicine(all)

Cite this

Bollati, V., & Baccarelli, A. (2010). Environmental epigenetics. Heredity, 105(1), 105-112. https://doi.org/10.1038/hdy.2010.2

Environmental epigenetics. / Bollati, V.; Baccarelli, A.

In: Heredity, Vol. 105, No. 1, 07.2010, p. 105-112.

Research output: Contribution to journalArticle

Bollati, V & Baccarelli, A 2010, 'Environmental epigenetics', Heredity, vol. 105, no. 1, pp. 105-112. https://doi.org/10.1038/hdy.2010.2
Bollati V, Baccarelli A. Environmental epigenetics. Heredity. 2010 Jul;105(1):105-112. https://doi.org/10.1038/hdy.2010.2
Bollati, V. ; Baccarelli, A. / Environmental epigenetics. In: Heredity. 2010 ; Vol. 105, No. 1. pp. 105-112.
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