Environmental exposure to dioxin: The Seveso experience

S. Signorini, P. M. Gerthoux, C. Dassi, M. Cazzaniga, P. Brambilla, N. Vincoli, P. Mocarelli

Research output: Contribution to journalArticlepeer-review


The toxicity in humans of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a man-made compound and environmental pollutant, is still debated. The industrial accident at Seveso, Italy, in 1976 exposed a large population of both sexes and of all ages to a massive concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Monitoring of soil and measurement of blood samples allowed classification of the exposed population into three categories: A, B and R (high, medium and low exposure, respectively). This article presents data from longitudinal health monitoring of the population, including liver function, immune function, neurological impairment, dermatological effects, reproductive pathology, and mortality.

Original languageEnglish
Pages (from-to)263-270
Number of pages8
Issue number4-5
Publication statusPublished - 2000


  • Environmental pollutants
  • Human health
  • Reproductive pathology
  • Sex ratio
  • TCDD

ASJC Scopus subject areas

  • Nephrology
  • Endocrinology


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